GPCR Annotator

GPCR Annotator Structural and functional information related to GPCRs and their ligands. http //www.jubilantbiosys.com... 

GPCR Annotator Jubilant Biosys 164 http //www.j ubilantbiosys. com/... 

Set the task of discovering new, previously unknown druggable receptors, how would we go about it In particular, how would we find a GPCR The first step toward functional annotation of a new GPCR sequence usually involves searching a primary sequence database with pairwise similarity tools. Such searches can reveal clear similarities between the query sequence... 

Fig. 2. WEB representation of SEVENS database. At the upper part (Fig. 2a), the chromosomal viewer, the phylogenetic map button, and the content search boxes are shown. Using the AND combinations of several conditions, the content search boxes retrieve GPCR genes. Selection of a query gene from these viewers or the list table navigates the user to the gene annotation information page.

The strategy of reverse pharmacology has turned out to be a generally applicable and productive approach for the deorphanization of GPCRs [63]. For example, it has been used for the functional annotation of the receptors Drostar-1 and Drostar-2, for which a role in visual information processing has been identified [64]. 

G-protein coupled receptors are classified according to the GPCR nomenclature available at http //www.gpcr.org/7tm, whereas nuclear receptors are annotated based on the NR nomenclature available at http //www.receptors.org/NR, 2006. 

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