Gonadotrope

Gurin164 has tabulated data from an examination of gonadotropic substances derived from several sources. The luteinizing hormone and the F. S. H. from the pituitary are stated to contain D-mannose and... 

Rimington and Rowlands165 have isolated an extremely active preparation from the serum of pregnant mares. This material was obtained in a high degree of purity and was shown to contain hexose and hexosamine in the molar ratio of 2/1. In the fractionation it appeared that, at first, the hexose content decreases as the potency is raised, but later this trend is reversed. It was shown that hexose content could not be taken as indication of gonadotropic activity. The hexose/hexosamine ratio was 2/1 as in normal serum mucoproteins, so that this gonadotropic hormone may be a modified serum mucoprotein. 

Childs, C.V., Lloyd, J.M., Unabia, C., Gharib, S.D., Wierman, M.E., and Chin, W.W. (1987) Detection of luteinizing hormone b messenger ribonucleic acid (RNA) in individual gonadotropes after castration Use of a new in situ hybridization method with a photobiotinylated complementary RNA probe. Mol. Endocrinol. 1, 926-932. 

Lactotropes, foli-cullostellate cells, corticotropes, and gonadotropes Lactotropes, foli-cullostellate cells, corticotropes, and gonadotropes Combined in situ hybridization and immunohisto-chemistry Mitchner et al. 1998... 

Gonadotropes Gonadotropes Dual immuno-labeling Childs et al. 2001... 

Gonadotropes Gonadotropes Dual immuno-labeling Sanchez-Criado et al. 2005... 

Lactotropes, somatotropes, thyrotropes, and gonadotropes Lactotropes, somatotropes, and gonadotropes Dualimmuno- labeling Gonzalez et al. unpublished... 

Fig. 5.6. Schematic diagram of estrogen (E2) actions on LH secretion in rat gonadotropes. Activation of nuclear ERa stimulates LH secretion (synthesis + release), whereas activation of nuclear ER/f modulates the effect of ERa on the synthesis, but not the release, of LH in a sort of ying-yang relationship. In addition, activation of putative membrane ERa by the cognate ligand would blunt the releasing effects of nuclear ERa activation by a potential, and as yet uncharacterized, cross-talk interaction...

DemayF, De Monti M, Tiffoche C, Vaillant C, Thieulant ML (2001) Steroid-independent activation of ER by GnRH in gonadotrope pituitary cells. Endocrinology 142 3340-3347... 

To stimulate spermatogenesis both testosterone and gonadotropic hormones need to be administered. 

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