Gomez Castano

Another approach is to use other cell-based systems that may have a higher sensitivity but still are representative for fish toxicity (Castano et al. 2003 Segner 2004). Since basal cytotoxicity reflects adverse effects on cell structures and processes that are intrinsic to virtually all cells, most cell systems should show a similar response, and respond similarly when toxicity is measured by various viability criteria. Mammalian cells that are cultured at higher temperatures and that proliferate faster than fish cells, may therefore be more sensitive and could provide a better in vitro system to predict acute fish lethality particularly if cell growth is considered as the endpoint (Castano et al. 2003 Segner 2004). Castano and Gomez-Lechon (2005) compared the sensitivity of fish and mammalian cell lines to 51 chemicals during 24 or 48 h exposure (Fig. 7.1). 

Castano A. Gomez-Lechon M.J. (2005) Comparison of basal cytotoxicity data between mammalian and fish cell lines A literature survey. Toxicology In Vitro 19 695-705. 

A.-1. Moreno-Vega, T. Gomez-Quintero, R.-E. Nuiiez-Anita, L.-S. Acosta-Torres, V. Castano, Polymeric and ceramic nanoparticles in biomedical applications. J. Nanotechnol. 2012 (2012) 1-10, doi 10.1155/2012/936041. 

Rodriguez-Lugo V, Ribio E, Gomez I, Torres-Martinez L, Castano VM (2002) Synthesis of silicon carbide from rice husk. Int J Environ Pollut 18 378-387... 

Astigarraga, E., Barreda-Gomez, G., Lombardero, L., Fresnedo, O., Castano. E, et al. (2008) Proflhng and imaging of lipids on brain and liver tissue by matrix-assisted laser desorption/ionization mass spectrometry using 2-mercap-tobenzothiazole as a matrix. Analytical Chemistry, 80, 9105-9114. 

Astigarraga, E., Barreda-Gomez, G., Lombardero, L., Eresnedo, O., Castano,... 

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