Gold-induced reactions

Ni Dhubhghaill, O.M., Sadler, P.J. and Tucker, A. (1992) Drug-induced reactions of bovine serum album proton NMR studies of gold binding and cysteine release. Journal of the American Chemical Society, 114, 1117-1118. 

The decline in the number of reports of parenter-ally administered gold-induced nephropathy may indicate that the dose of gold salts used per injection is decreased and intervals between injections are being extended to prevent adverse reactions. Furthermore, introduction of methotrexate therapy for rheumatoid arthritis has contributed to decreased reliance on gold salts. 

Gottlieb NL, Gray RG. Diagnosis and management of adverse reaction from gold compounds. J Analytic Toxicol 1978 2 173. Baldwin JL, Storb R, Thomas ED, Mannik M. Bone marrow transplantation in patients with gold-induced marrow aplasia. Arthritis Rheum 1977 20 1043-1048. 

In 2006, Asao and Sato developed the synthesis of 9-acylanthracenes 60 by the gold(I)-catalyzed reaction of ( -alkynyl(oxo)arenes 58 with benzyne, generated from benzenediazonium 2-carboxylate 59 (Scheme 28.22) [33]. The reaction proceeds through [4 - - 2] cycloaddition between benzyne and benzopyrylium auricate complex 61, arising from the gold-induced cyclization of 58. 

Density Functional Theory (DFT) has shown that low-coordinated sites on the gold nanoparticles can adsorb small inorganic molecules such as O2 and CO, and the presence of these sites is the key factor for the catal5dic properties of supported gold nanoclusters. Other contributions, induced by the presence of the support, can provide parallel channels for the reaction and modulate the final efficiency of Au-based catalysts. Also these calculations extended for the adsorption of O and CO on flat and... 

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