Gold complexes, oxidative

Thiirane is more bactericidal than oxirane, and derivatives of 2-mei captomethylthiirane inhibit tuberculosis. The following pharmacological uses have been reported for compounds derived from thiirane derivatives gold complexes of the adducts of diethylphosphine and thiirane (antiarthritic), adducts of thiiranes and malononitrile (antibacterial, blood vessel dilators, muscle relaxants, sedatives), thermolysis products of thiirane 1-oxides and adducts of thiirane 1-oxides with sulfenyl chlorides (antibacterial), adducts of 2,3-diarylthiirene 1,1-dioxides with ynamines (antibacterial, parasiticidal), adducts of 2,3-diarylthiirene 1,1-dioxides with enamines (antifertility), adducts of p-aminophenylacetic esters with thiirane (immunosuppressants), adducts of amines and thiiranes (radioprotective drugs). 

The oxidation-reduction reactions of gold complexes. V. P. Dyadchenko, Russ. Chem. Rev. (Engl. Transl), 1982, 51,265-271 (66). 

A related dinuclear species 77, recently described, constitutes the first dinuclear gold(I) complex with heterobridged phosphor-1,1 -dithiolato moieties and bis(ylide) bridging ligands [ 102]. It is obtained by reaction between [ AuS2PPh2] and the diylide gold complex 74 (R=Me). No intermolecular Au-Au interaction is observed in 77 but the oxidative addition of chlorine to the product leads to a new complex 78 in which a single bond is formed between the two Au(II) centers (Scheme 26). 

The small amounts of gold contained in low-grade ores can be extracted using a combination of oxidation and complexation. Gold is oxidized to Au, which forms a very strong complex with cyanide anions Au ((2 q) + l CN(a q) [Au (CN)2] aq) K -lx 10 Suppose that a sample of ore containing 2.5 X 10 mol of gold is extracted with 1.0 L of 4.0 X 10 M aqueous KCN solution. Calculate the concentrations of the three species involved in the complexation equilibrium. 

Abdou, H. (2006) PhD. Thesis New Chemistry with Gold-Nitrogen Complexes Synthesis and Characterization of Tetra-, Tri-, and Dinuclear Gold(I) Amidinate Complexes. Oxidative-Addition to the Dinuclear Gold (I) Amidinate, A M University, Texas. 

Guzman, J. and Gates, B.C. (2003) Structure and reactivity of a mononuclear gold-complex catalyst supported on magnesium oxide. Angewandte Chemie International Edition, 42, 690-693. 

Trzcinskabancroft, B., Knachel, H., Dudis, D., Delord, T.J. and Marler, D.O. (1985) Experimental And Theoretical-Studies Of Dinudear Gold(I) And Gold(II) Phosphorus Ylide Complexes - Oxidative Addition, Halide Exchange, And Structural-Properties Including The Crystal And Molecular-Structures Of [Au (CH2)2PPh2]2 And [Au(CH2)2PPh2]2(CH3) Bri. Journal of the American Chemical Society, 107(24), 6908-6915. 

This scheme shows that cyanide sourced from smoking or otherwise (see 6.3.7) may determine the metabolism of chrysotherapeutic agents. [Au(CN)2] anions bind to serum albumin predominantly by the formation of adducts without the displacement of cyanide [94]. The ions bind tightly to albumin independent of the oxidative state of Cys-34. The equilibrium constant values for [Au(CN)2] binding to serum albumin are similar to values for other gold complexes that bind to albumin. This indicates that albumin can act as a carrier for transporting [Au(CN)2] in the bloodstream. 

The approach comprises deposition-precipitation (DP) of Au(OH)3 onto the hydroxide surfaces of metal oxide supports from an alkaline solution of HAUCI4 [26] and grafting of organo gold complexes such as dimethyl gold (Ill)acetylacetonate (hereafter denoted as Au acac complex) [27] and Au(PPh3)(N03) [28] either in gas and liquid phase are advantageous in that a variety of metal oxides commercially available in the forms of powder, sphere, honeycomb can be used as supports. 

The Au(ll) oxidation state was also observed in cyclometalated gold dimers [386, 387] and in gold complexes of hA(diphenylphosphino)amine [388]. The specific feature of these Au(ll) complexes is that their 6 - A q relation is located midway between that of Au(l) and Au(lll) complexes. 

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