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Gold anticancer complexes

We have examined a class of gold(III) complexes using an integrated approach to the search for new metal-based anticancer drugs. This incorporates inorganic medicinal chemistry, in vitro screening, in vivo human tumour xenograft models and mechanistic studies. [Pg.780]

In 2008, Filipovska and coworkers reported a comparison between cationic and neutral gold(I) complexes as potential anticancer drugs based on the results obtained from the mitochondrial assay [10]. [Pg.205]

Gold coordination complexes as anticancer agents, I. Kostova, Anti-Cancer Agents Med. Chem., 2006,6,19. [Pg.229]

Vergara E, Casini A, Sorrentino F et al (2010) Anticancer therapeutics that target selenoenzymes synthesis, characterization, in vitro cytotoxicity, and thioredoxin reductase inhibition of a series of gold(l) complexes containing hydrophilic phosphine ligands. Chem Med Chem 5 96-102... [Pg.460]

Hartinger, C. G., Phillips, A. D. Nazarov, A. A. Polynuclear Ruthenium, Osmium and Gold Complexes. The Quest for Innovative Anticancer Chemotherapeutics. Cwrr. Top. Med. Chem. 11, 2688-2702 (2011). [Pg.6]

Rackham O, Nichols SJ, Leedman PJ, Bemers-Price SJ, Filipovska A (2007) A gold(I) phosphine complex selectively induces apoptosis in breast cancer cells implications for anticancer therapeutics targeted to mitochondria. Biochem Pharmacol 74 992-1002... [Pg.79]

All the gold compounds used in therapy today (chrysotherapy) are Au(I) compounds (45-47) (10-14). Gold has an intriguing chemistry dominated hy relativistic effects (48) and it is interesting to consider the reasons why Au(III) complexes are not used as anticancer agents like those of Pt(II) are used. [Pg.17]

See other pages where Gold anticancer complexes is mentioned: [Pg.190]    [Pg.80]    [Pg.69]    [Pg.34]    [Pg.781]    [Pg.520]    [Pg.779]    [Pg.781]    [Pg.189]    [Pg.147]    [Pg.156]    [Pg.164]    [Pg.187]    [Pg.79]    [Pg.266]    [Pg.266]    [Pg.268]    [Pg.268]    [Pg.611]    [Pg.173]    [Pg.151]    [Pg.268]    [Pg.216]    [Pg.774]    [Pg.969]    [Pg.6447]    [Pg.371]    [Pg.759]    [Pg.618]    [Pg.22]    [Pg.774]    [Pg.969]    [Pg.444]    [Pg.109]    [Pg.455]    [Pg.779]    [Pg.64]    [Pg.6446]    [Pg.6919]   
See also in sourсe #XX -- [ Pg.446 , Pg.447 , Pg.448 , Pg.449 , Pg.450 , Pg.451 , Pg.452 , Pg.453 ]



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