Glyset - Miglitol

Glyset (Miglitol). Pharmacia Upjohn Campai. US Prescribing information, October 2004. 

The a-glucosidase inhibitors, acarbose (Precose) and miglitol (Glyset), lower blood sugar by delaying die digestion of carbohydrates and absorption of carbohydrates in the intestine. 

Acarbose (Precose) and miglitol (Glyset) are dosed similarly. Therapy is initiated with a very low dose (25 mg with one meal a day) and increased very gradually (over several months) to a maximum of 50 mg three times daily for patients weighing 60 kg or more, or 100 mg three times daily for patients above 60 kg. The drugs should be taken with the first bite of the meal so that the drug is present to inhibit enzyme activity. 

Glyset 25-100 mg (miglitol) One tab tid with the first bite of each meal... 

Miglitol (Glyset) Hypoglycemic Tab 25, 50,100 mg 25 mg tid, then 50-100 mg tid with the first bite of each meal. Delays carbohydrate absorption. Rash, Gl upset... 

Miglitol (Glyset) is another a-glucosidase inhibitor, but in contrast to acarbose, mightol is systemically absorbed prior to its activity in the small intestine. It also appears to inhibit the enzymes sucrase and maltase to a greater extent than does acarbose. It does not undergo metabolism and is renally excreted unchanged. 

Miglitol (Glyset) [Hypoglycemic/Alpha Glucosidase Inhibitor]... 

Acarhose or Miglitol and Food. Some medications should be administered with food for optimum benefit. Acarbose (Precose) and miglitol (Glyset) are effective in the treatment of diabetes mellitus because they delay the digestion of ingested carbohydrates and reduce the elevation of blood glucose concentrations following meals. Maximum effectiveness is attained when doses are administered at the start (with the first bite) of each main meal. 

An alpha-glucosidase inhibitor, acarbose (Precose) or miglitol (Glyset), is administered to allow carbohydrates to pass slowly through the intestine. Glucophage does not do this. 

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