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Glycosylations, with transferases glycosylation

High selectivity and substrate specificity of glycosyl transferases make them valuable catalysts for special linkages in polymer-supported synthesis. There is, however, still a rather limited set of enzymes available to date, and the need to synthesize a variety of natural and non-natural oligosaccharides prevails. Particularly with regard to combinatorial approaches, chemical solid-phase oligosaccharide synthesis promises to meet the demands most effectively. [Pg.11]

A hexaglycine spacer was attached to the solid support to give a substitution of 0.2 mmol g of dry silica and the excess amino groups were then capped using acetic anhydride. In the next step a selectively cleavable, a-chymotrypsin sensitive, phenylalanine ester (2) was implemented for the release of the products from the solid support under mild conditions. Subsequently it was transformed to (3) followed by reactions with glycosyl transferases to yield (4). Finally, the desired glycopeptide was cleaved from the solid support in high yield by treatment of (4) with a-chymotrypsin (Scheme 10.1). [Pg.447]

Starch Liquefaction with a Highly Thermostable Cyclodextrin Glycosyl Transferase from Thermoanaerobacter Species... [Pg.384]

Recent developments in the enzymatic synthesis of carbohydrates can be classified into four approaches 1) asymmetric C-C bond formation catalyzed by aldolases (1-10 2) enzymatic synthesis of carbohydrate synthons (loll) 3) asymmetric glycosidic formation catalyzed by glycosidases (12.-17) and glycosyl transferases (18-23.) and 4) regioselective transformations of sugars and derivatives (24-25). These enzymatic transformations are stereoselective and carried out under mild conditions with minimum protection of functional groups. They hold promise in preparative carbohydrate synthesis. In connection with this book, we focus on the first two approaches. [Pg.317]


See other pages where Glycosylations, with transferases glycosylation is mentioned: [Pg.175]    [Pg.218]    [Pg.178]    [Pg.291]    [Pg.127]    [Pg.679]    [Pg.520]    [Pg.523]    [Pg.270]    [Pg.288]    [Pg.251]    [Pg.295]    [Pg.20]    [Pg.46]    [Pg.166]    [Pg.168]    [Pg.44]    [Pg.145]    [Pg.84]    [Pg.304]    [Pg.146]    [Pg.146]    [Pg.289]    [Pg.648]    [Pg.196]    [Pg.449]    [Pg.384]    [Pg.385]    [Pg.68]    [Pg.57]    [Pg.254]    [Pg.195]    [Pg.344]    [Pg.157]    [Pg.243]    [Pg.314]    [Pg.519]    [Pg.45]    [Pg.494]    [Pg.245]    [Pg.266]   
See also in sourсe #XX -- [ Pg.231 ]




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Glycosyl transferases

Glycosylation with transferases

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