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Glycosaminoglycans, acidic, biosynthesis

Biosynthesis and degradation of glycosaminoglycans biosynthesis of collagen, mineralization and demineralization of bone. Fatty acid synthesis and triglyceride storage in adipocytes promoted by insulin and triglyceride hydrolysis and fatty acid release stimulated by glucagon and adrenaline (epinephrine). [Pg.283]

It seems probable that other L-hexuronic acids listed in Table III, such as L-iduronic,208 2-amino-2-deoxy-L-altruronic,209 and 2,3-diamino-2,3-dideoxy-L-guluronic210 acids may arise in bacterial polymers as a result of epimerization at C-5 at the polymer level. Such a pathway was demonstrated for the biosynthesis of L-idosyluronic acid residues in glycosaminoglycans of higher animals.211 212... [Pg.297]

See also Biosynthesis of Glycoconjugates, Glycoproteins (from Chapter 9), Glycosaminoglycans, Hyaluronic Acid, Structural Polysaccharides, UDP-N-Acetylgalactosamine... [Pg.750]

The data available on the biosynthesis of chondroitin 4-sulfate proteoglycan has been suflBcient to permit the presentation in schematic form of many of the stages in the transformation from amino acid right through to complete glycosaminoglycan (K28) (Scheme 1). [Pg.29]

Biosynthesis. — Up to 56% of sulphated glycosaminoglycans synthesized by explant cultures of human and rabbit articular chondrocytes are located in the trypsin-digestible pericellular coat. ° Sulphate is incorporated into both D-glucopyranosyluronic acid and L-idopyranosyluronic acid residues in hybrid glycosaminoglycans by monolayers of chick embryo arterial fibroblasts. Several oligosaccharides, released on treatment with chondroitin lyase ABC and chondroitin lyase AC, have been characterized. [Pg.359]

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