Glycoproteins classification

L. (2005) Classification of substrates and inhibitors of P-glycoprotein using unsupervised machine learning approach. Journal of Chemical Information and Computer Sciences, 45, 750-757. 

The possibility of categorizing glycoproteins according to the nature of the carbohydrate-peptide bond contained has been suggested.38 To some extent, this method is possible, but, as was pointed out, it does not result in a rigid classification, for examples are known in which more than one type of carbohydrate moiety is attached to a given polypeptide chain. 

The glycoproteins, together with the glycolipids, constitute the class of the glycoconjugates, the classification of which is given in Fig. 1 that is, the glycoconjugates are the products of association between a carbohydrate, which is called a glycan, with either a protein or a lipid. 

Didziapetris R, Japertas P, Avdeef A, Petrauskas A. classification analysis of P-glycoprotein substrate specificity. J Drug Target 2003 11 391-406. 

Various transporter proteins were assessed including P-glycoprotein (P-gp). The K-PLS classification models for P-gp substrates (Table 15.2, panel A) and K-PLS regression models for P-gp inhibitors (Table 15.2, panel B) were found to represent a slight improvement over PLS. The difference in favor of K-PLS is more pronounced for the noradrenaline transporter and serotonin transporter dissociation constant models (Table 15.2, panels C, D). 

Didziapetris, R., Japertas, P., Avdeef, A. and Petrauskas, A. (2003) Classification analysis of P-glycoprotein substrate specificity. Journal of Drug Targeting, 11, 391 106. 

Cell adhesion molecules (CAMs) are transmembrane glycoproteins that act at the cell surface to mediate specific binding interactions with other cell adhesion molecules on adjacent cells or with proteins in the extracellular matrix. They are responsible for the adhesion of various leukocytes with each other, with extracellular matrix and with other cell types. There are four families of CAMs that facilitate these interactions. The classification is based on differences in struchue and includes selectins, cadherins, integrins, and immunoglobulin superfamily (Table 9). CAMs play a role in renal morphogenesis and are expressed in the adult human kidney. These molecules can influence growth factor expression, and conversely growth factors can modulate production of cell surface adhesion molecules and the expression of extracellular matrix proteins. 

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