Glycopolymers polymers

Figure 15.3 Various strategies leading to dendronized or hyperbranched glycopolymers. (A) grafting of dendronsto pre-formed polymers (B) polymerization of dendron monomers (C) grafting dendrimers on pre-formed polymers...

Some reviews have been published on the synthetic carbohydrate-based polymers and glycopolymers [11-15]. However, they refer mainly to poly(vinylsaccharide)s and other conventional functionalized polymers having sugars as groups pendant from the main chain of the polymer. In this chapter we shall describe those sugar-based monomers which lead to polymers having the sugar units incorporated into... 

Figure 13.4 A schematic showing some of the frameworks that have been reported for the study of protein-carbohydrate interactions. Carbohydrates are represented as cyclohexane. (Top) Glycodendrimer, carbohydrate-functionalized nanoparticle, and star polymer. (Bottom) Linear glycopolymer, carbohydrate-functionalized protein, and carbohydrate-functionalized surface.

Miyata T, Nakamae K (1997) Polymers with pendant saccharides - glycopolymers . Trends Polym Sci 5(6) 198-205... 

Reineke TM (2006) Poly(glycoamidoamine)s cationic glycopolymers for DNA delivery. J Polym Sci A Polym Chem 44(24) 6895-6908... 

Glycopolymers, consisting of sugar residues attached to a polymer backbone, have emerged as important tools for the investigation of sugar-protein inter-actions.8a,77j 95... 

Polymer adsorption has also been adapted to QCM sensing whereby biofunctional thin films are adsorbed on the crystal surface with non-specific binding controlled by tuning of polymer composition. This approach proved successful as applied to carbohydrate-protein interaction by Matsuura et al. through adsorption of lactose bearing amphiphilic polymers on hydrophobic surfaces which then showed RCA12o and peanut lectin (PNA) affinity [33]. Carbohydrate surfaces prepared by photo insertion into an adsorbed polymer were tested by QCM and showed the predicted affinities [34] while in another example a covalently bound glycopolymer demonstrated Concanavalin A detection ability [35]. 

Keywords Carbohydrate sugar glyco polysiloxane glycopolysiloxane hydrosilylation polymer glycopolymer... 

Kim B and Peppas NA. Synthesis and characterisation of pH-sensitive glycopolymers for oral dmg delivery systems. Journal of Biomaterials Science, Polymer Edition 2002 13 1271-1281. 

Perfluoroalkyl groups are also introduced into block copolymers with methacrylates, acrylates, and styrene (B-46 to B-53), which can be synthesized in scCC>2 or in the bulk.95,315 Amphiphilic block copolymers based on glycopolymer segments (B-54 and B-55) are synthesized by copper-catalyzed polymerizations.321,322 Comonomers with a polyhedral oligomeric silsesquioxane unit afforded hybrid polymers between organic and inorganic components (B-56 and B-57).326... 

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