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Synthetic glycopeptides

With the emergence of bacterial strains that are resistant to these glycopeptides, the first line of defense is often to synthetically modify the natural antibiotic. In the case of these glycopeptides, synthetic alteration of the aglycone stmcture is not practical, due to their complexity. However, the carbohydrate portion of the molecule [vancosamine(a l-2)glucose in the case of vancomycin] is readily accessible to modification. This strategy has led to new antibiotics that have potential for treatment of vancomycin-resistant strains. [Pg.1832]

Huang J, Habraken G, Audouin F, Heise A (2010) Hydrolytically stable bioactive synthetic glycopeptide homo- and copolymers by combination of NCA polymerization and click reaction. Macromolecules 43 6050-6057... [Pg.26]

Warren JD, Geng X, Danishefsky SJ (2007) Synthetic Glycopeptide-Based Vaccines. 267 109-141... [Pg.266]

Koganty, R.R., Reddish, M.A., and Fongenecker, B.M. (1996) Glycopeptide- and carbohydrate-based synthetic vaccines for the immunotherapy of cancer. Drug Disco. Today, 1, 190-198. [Pg.1084]

The afore-mentioned results have stimulated an interest in the synthesis of glycopeptides for the purpose of supplying structurally well-defined derivatives as models for biochemical and immunochemical studies. Synthetic... [Pg.277]

Although the limitations of the enzymic reactions lie in the substrate selectivity and in the availability of enzymes and appropriate nucleotide sugar derivatives, further developments in this field will offer an interesting and efficient potential for the synthetic construction of glycopeptides of biological interest. [Pg.306]

The most effective and general route to synthetic glycopeptides includes the employment of glycosylated amino acids in stepwise solid-phase syntheses based on... [Pg.257]

SYNTHETIC STRATEGIES FOR THE PREPARATION OF GLYCOPEPTIDES CONTAINING CSPs FOR HPLC... [Pg.124]

Scheme 2.1 General synthetic schemes for the immobilization of macrocyclic antibiotics. (a) (i) 1,6-Diisocyanatohexane (ii) glycopeptide (TE, TAG, and A-40,926). (b) (i) Glycopeptide (eremomycin, ristocetin A, vancomycin), (c) (i) NaI04 (ii) glycopeptide (vancomycin, ristocetin A, MDL 63,246). (d) (i) 3-Isocyanatopropyl-silyl derivative of macrocyclic antibiotic (TE, rifamycin B, vancomycin, DMP-vancomycin, NVC). Scheme 2.1 General synthetic schemes for the immobilization of macrocyclic antibiotics. (a) (i) 1,6-Diisocyanatohexane (ii) glycopeptide (TE, TAG, and A-40,926). (b) (i) Glycopeptide (eremomycin, ristocetin A, vancomycin), (c) (i) NaI04 (ii) glycopeptide (vancomycin, ristocetin A, MDL 63,246). (d) (i) 3-Isocyanatopropyl-silyl derivative of macrocyclic antibiotic (TE, rifamycin B, vancomycin, DMP-vancomycin, NVC).
Judice JK, Pace JL. (2003) Semi-synthetic glycopeptide antibacterials. [Pg.139]

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See also in sourсe #XX -- [ Pg.190 ]



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