Glycopeptides liquid chromatography separation

Ahoul-Enein, H.Y. and Ali, I. Macrocyclic glycopeptide antihiotics-hased chiral stationary phase, in Chiral Separation by Liquid Chromatography and Related Technologies, Marcel Dekker New York, 2003, chap. 2. 

Fanah, S. et al.. Use of short-end injection capiUary packed with a glycopeptide antibiotic stationary phase in electrochromatography and capiUary liquid chromatography for the enantiomeric separation of hydroxy acids, J. Chromatogr. A, 990, 143, 2003. 

W. S., Armstrong, D. W. Separation of chiral sulfoxides by liquid chromatography using macrocyclic glycopeptide chiral stationary phases, J. Chromatogr. 

Since first demonstration in 1994 of the potential use of macrocyclic antibiotics as chiral selectors in analysis, glycopeptide antibiotics have been successfully applied for enantiomer separations by liquid chromatography, as recognition components of chiral stationary phases, and by capillary electrophoresis (CE) as soluble chiral selec-tors. Four chiral stationary phases for chromatography with the selectors vancomycin, ristocetin, teicoplanin, and the teicoplanin aglycone are commercialized under the trade name Chirobiotic by Astec and Supelco. Various aspects of analytical applications of glycopeptide antibiotics have been extensively covered in the recent reviews cited above. As an example. Table 2 shows some representative results for CE enantioseparations with vancomycin, ristocetin A, and teicoplanin, which were taken from Ref. 39. 

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