Glycopeptides broad applicability

The broad applicability of glycopeptides is assumed to be based on the interactions with the analyte of various functional groups being part of the glycopeptide molecule. These comprise hydrophobic, dipole-dipole-, ti-ti-, and ionic interac-... 

Schwarz, J B, Kuduk, S D, Chen, X-T, Sames, D, Glunz, P W, Danishefsky, S J, A broadly applicable method for the efficient synthesis of a-O-linked glycopeptides and clustered sialic acid residues, J. Am. Chem. Soc., 121, 2662-2673, 1999. 

Because of their diverse functionality, it is not surprising to see that CSPs based on macrocyclic glycopeptides, i.e., Chirobiotic phases, have a broad-spectrum applicability in all HPLC conditions, namely normal-phase, reversed-phase, polar organic,... 

Abstract The macrocyclic glycopeptide chiral selectors are natural molecules produced by bacterial fermentation. Purified and bonded to silica particles, they make very useful chiral stationary phases (CSP) with a broad spectrum of applicability in enantiomeric separation. The macrocyclic glycopeptide CSPs are multimodal, the same column being able to work in normal phase mode with apolar mobile phase, in reversed-phase mode, or in polar ionic mode with 100% alcoholic mobile phase... 

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