Glycopeptide templates

Preparation and Analysis of Solid-Phase Glycopeptide Template Libraries... 

Systematic investigations of mannose-binding proteins with clustered mannosides other than natural multiantennary oligosaccharides have been rather scarce until recently. However, using 6 -0-phosphorylated mannose disaccharide scaffolded on peptide templates using combinatorial glycopeptide libraries. 

M. Halkes, . H. Gotfredsen, M. Grotli, L. P. Miranda, J. O. Duus and M. Meldal, Solid-phase glycosylation of peptide templates and on-bead MAS-NMR analysis Perspectives for glycopeptide libraries, Chemistry-A European Journal, 2001, 7, 3584-3591. 

A short introduction to peptide synthesis will be given before the synthesis of glycopeptides is discussed. Proteins are assembled by a nucleic acid templated reaction from a menu comprising 19 L-oc-amino acids of general structure 1 and the amino acid L-proline (2) (Figure 5.1). Nature synthesises proteins by a stepwise assembly of amino acid building blocks. Since these compounds are readily available in... 

As a consequence of the progress and success of diverse oligomer libraries, experts in combinatorial synthetic oligomers, glycopeptide and oligosaccharide libraries, RNA-and DNA-aptamers have each contributed their news in these fields, while novel experimental examples of the use of templates in combinatorial chemistry for the solid-phase synthesis of multiple core structure libraries provide some insight to praxis-relevant work. 

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