Metabolic enzymes glycolytic cycle

Biochemical systems are also often reaction cycles where the key catalytic intermediate is generated, consumed, and subsequently regenerated as the part of the complex reaction cycle. Enzymes catalyze the formation of the intermediates that participate in the overall reaction cycle. These are intricately catalyzed reaction systems where the intermediates that form subsequently act as catalysts. The citric acid cycle, which was discussed in Section 2.1 (see also Fig. 2.5), is one such cycle. Two other complex reaction systems comprised of many catalytic steps that are of key metabolic importance are the Calvin and glycolytic cycles. 

As we look at some of the reactions of intermediary metabolism, we shall rationahze them in terms of the chemistry that is taking place. In general, we shall not consider here the involvement of the enzyme itself, the binding of substrates to the enzyme, or the role played by the enzyme s amino acid side-chains. In Chapter 13 we looked at specific examples where we know just how an enzyme is able to catalyse a reaction. Examples such as aldolase and those phosphate isomerase, enzymes of the glycolytic pathway, and citrate synthase from the Krebs cycle were considered in some detail. It may... 

Braun-Falco and Petzoldt (B30), Rassner (Rl), and Halprin and Ohkawara (H2) presented extensive surveys of the glycolytic, pentose shunt, and citric acid cycle enzymes in normal skin, unaffected skin of psoriatic patients, and in the lesions themselves. Figure 10 is reprinted from this work (H2) and shows the reorganization of the cellular metabolic activity made necessary by the high synthetic and mitotic rate of the tissue. 

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