Glycolipid metabolism

Whereas the activities of CMP-NeuNAc lactosylceramide sialyltransferase increase postnatally (38), the activities of the CMP-NeuNAc glycoprotein sialyltransferase decline dramatically during early development (17). Separate regulatory controls on the glycoprotein and glycolipid metabolism have also been implicated in a study on the brain tissues of Tay-Sachs disease patients. 

Actovegin is a deproteinized product extracted from the blood of 6-month-old calves. It consists of oligosaccharides, nucleotides, low-molecular-weight polypeptides, glycolipids, metabolic intermediates of saccharides and Imids, amino acids, and trace elements Adverse drug... 

Increasing knowledge about the function and metabolism of these substances will presumably lead to increased pharmacological interest in this field. The treatment of sphingoUpidoses or the use of drugs that interfere with glycolipid metabolism to modulate membrane functions will be hot topics for research in the future. A new and exciting development is the involvement of... 

A large part of the sphingolipids are present as glycolipids. Metabolic Pathway 2, shown below, indicates the known routes of formation of the major nucleotide monosaccharide intermediates i.e. UDPgal, UDPglc, UDPgalNAc and CMPneu-... 

Austin, J. H., A. S. Balasubramanian, T. N. Pattabiraman, S. Saraswath, D. K. Basu, and B.K. Bachawat Controlled study of enzyme activities in three human disorders of glycolipid metabolism. J. Neurochem. 10, 805 (1963). 

Lingwood CA, Hakomori S Selective inhibition of cell growth and associated changes in glycolipid metabolism induced by monovalent antibodies to glycolipids. Exp. Cell Res. 1977 108 385-391. 

Our interest in complex lipids in neoplastic cells was initiated through an investigation of glycolipid metabolism in human leukocytes. It was observed that white blood cells from normal individuals contain several sphingolipid hydrolases. The activity of these enzymes in leukocytes parallels that in systemic organs and tissues. For example, the activity of glucocerebrosidase (reaction 1) is diminished in patients with... 

Fishman, P. H., Brady, R. O., and Mora, P. T., 1973, Altered glycolipid metabolism related to viral transformation of established mouse cell lines, in Tumor Lipids Biochemistry and Metabolism (R. Wood, ed.), pp. 251-266, American Oil Chemists Society, Chicago. 

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