Glycogen Convulsions

Be Pyridoxine, pyridoxal, pyridoxamine Coenzyme in transamination and decarboxylation of amino acids and glycogen phosphorylase role in steroid hormone action Disorders of amino acid metabolism, convulsions... 

Although there are no data from human studies that indicate that hepatic effects occur in humans exposed to heptachlor, the animal studies indicate that the liver is a target organ for this chemical and is more sensitive to low doses than the neurological system. Decreased glycogen, increased cholesterol, GOT, and AP enzyme levels, and increased liver weight were reported in mice fed heptachlor at 0.5 mg/kg/day. In contrast, neurological effects such as convulsions were observed in a cow fed 2.5 mg/kg/day heptachlor daily for 15 days (Buck et al. 1959). Increased liver enzymes could indicate exposure to heptachlor, but this would not be a marker specific to this chemical. Refer to Section 2.2 for a detailed discussion of the effects caused by heptachlor and heptachlor epoxide. 

Dieldrin CNS effects (tremors convulsions, coma), nausea, vomiting Carcinogen (animal positive), liver damage (glycogen depletion, fatty infiltration, necrosis), kidney damage (fatty changes, necrosis)... 

The convulsions often observed in patients with von Gierke s disease probably result from this susceptibility to develop hypoglycemia. Because glucose-6-phos-phatase deficiency involves no block in glycogen synthesis or breakdown, anomalies in the glycogen structure are not expected, and the glycogen that accumulates has a molecular structure identical to that of tissues of normal individuals. 

Klein, J.R., Olsen, N.S., 1947. Effect of convulsive activity upon the concentration of brain glucose, glycogen, lactate, and phosphates. J. Biol. Chem. 167, 747-756. 

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