Oxidation glycine

Threonine. Threonine is cleaved to acetaldehyde and glycine. Oxidation of acetaldehyde to acetate is followed by formation of acetyl-CoA (Figure 30-10). Catabolism of glycine is discussed above. 

CASRN 56-40-6 molecular formula C2H5NO2 FW 75.07 Chemical/Physical Products identified from the oxidation of glycine and OH radicals (generated from H2O2/UV) in oxygenated water were oxalic acid, formic acid, and ammonium ions. In oxygen-free water, oxalic and formic acids were not produced, i.e., glycine oxidized directly to ammonium ions. The rate constant for the reaction of OH radicals with the zwitterion ion is 1.7 X 10 /M-sec and with the anionic form is 1.9 x 10 /M-sec (Vel Leitner et al., 2002). 

Protein synthesis Glycogen synthesis Lactate uptake Amino acid uptake Glutaminase Glycine oxidation Ketoisocaproate oxidation Acetyl-CoA carboxylase Urea synthesis from amino acids Glutathione (GSH) efflux Taurocholate excretion into bile Actin polymerization Microtubule stability Lysosomal pH... 

Often cyanide is produced by glycine oxidation, allowing to translate effects of selective metal sequestration by comparing mono- and bidentate c and x values for the given metal. 

Althongh glyoxalate can be transaminated back to glycine, this is not really considered a biosynthetic ronte for new glycine, becanse the primary ronte for glyoxylate formation is from glycine oxidation. 

In order to estimate the rate of glycine oxidation we compared the oxidation of glycine to oxidation of other substrates. The ratios of the glycine oxidation rate relative to the oxidation rates of malate, succinate and NADH in the presence of ADP, i.g. state III, are shown in Table I. 

Photorespiratory metabolism is occuring only in photosynthetic cells as phosphoglycolate is a product of the Rubisco reaction, and Rubisco is present only in these cells. In spite of this, we find substantial rate of glycine oxidation not only in mitochondria isolated from green leaves, but also in... 

It was proposed by Shemin and Russell ( 9) that 5-AL not only gave rise to porphyrins but could be oxidized back to succinic acid. This would provide an alternate path for glycine oxidation. It is difficult to obtain a quantitative idea of the amount of 5-AL that is decomposed via this cycle. Experiments from Neuberger s laboratory (391) suggested that perhaps 30 % of the 5-AL formed may undergo oxidation. The complex relation of glycine metabolism and porphyrin synthesis has recently been carefully analyzed by Neuberger (55). 

Fio. 10. The Shemin cycle for glycine oxidation with succinate as catalyst (t9). 

The presence of ammonia in alkaline solutions (naturally, in the form of ammonium cation) after the end of the process of glycine oxidation was fixed by means of a qualitative reaction using the Nessler reagent by the technique, described in [32]. To specify the nature of other products of glycine and a-alanine electrooxidation in alkaline medium FTIR-spectra... 

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