Glycogen enzymic synthesis

In the case of glycogen, no corresponding definite boundary conditions exist during enzymic synthesis, and hence it may have a true three-dimensional structure. 

The flow of intermediates through metabolic pathways is controlled by 1bir mechanisms 1) the availability of substrates 2) allosteric activation and inhibition of enzymes 3) covalent modification of enzymes and 4) induction-repression of enzyme synthesis. This scheme may at first seem unnecessarily redundant however, each mechanism operates on a different timescale (Figure 24.1), and allows the body to adapt to a wde variety of physiologic situations. In the fed state, these regulatory mechanisms ensure that available nutrients are captured as glycogen, triacylglycerol, and protein. 

Manners, D. J., Enzymic Synthesis and Degradation of Starch and Glycogen, 17, 371-430... 

With the recent identification of the anomalous linkages in amylose as a-D-(l 6)-glucosidic inter-chain linkages, the metabolism of starch and glycogen can be adequately considered in terms of the enzymic synthesis and degradation of only two types of n-glucosidic linkage, namely, a-D-(l— 4) and a-n-(l- ). 

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