Glycine, oligomer

In all cases, glycine oligomers were obtained, from the dimer up to the decamer yields were pressure dependent. The rate of polymerisation increased during the first 8 days and then remained constant until the 31st day. The authors conclude from their experimental results that abiotic polymerisation reactions during diagenesis were more likely to have occurred in deep-lying sediments than in the primeval ocean (Ohara et al 2007). 

Figure 7.6—Gel filtration chromatograms. The separation of glucose oligomers is shown to the left. Peak number 1 corresponds to glucose (Af — 180) and peaks are seen every approximately 20 units (M = ca. 2 000). (Reproduced by permission of Polymer Lab.) The right portion of the figure shows the separation of a mixture of proteins and glycine oligomers. (Reproduced by permission of Pharmacia-Biotech.)...

Figure 7.6 Gel filtration chromatogram. Left, separation of a mixture of glucose oligomers ranging from a single unit (glucose M = 180), up to 20 units (M around 3000) (reproduced courtesy of Polymer Lab). Right, separation of a mixture of diverse proteins and glycine oligomers (reproduced courtesy of Pharmacia-Biotech).

Scheme 10.18 N-substituted glycine-oligomers functionalized by click chemistry...

Culf AS, Ouellette RJ (2010) Solid-phase synthesis of N-substituted glycine oligomers (a-peptoids) and derivatives. Molecules 15 5282-5335... 

The development of the aminoethylglycine polyamide (peptide) backbone oligomer with pendant nucleobases linked to the glycine nitrogen via an acetyl bridge now often referred to by PNA (peptide nucleic acid Fig. 4.1), was inspired... 

The reaction mixture consisted only of glycine and water, without the addition of salts or other condensation catalysts. A stepwise, time-dependent synthesis of oligomers up to hexaglycine was observed. On addition of Ca2+ ions (pH 2.5), the oligomerisation continued further to give octaglycine. 

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