Glycine aminoacetic acid

Dissolve 180 g. of commercial ammonium carbonate in 150 ml. of warm water (40-50°) in a 700 ml. flask. Cool to room temperature and add 200 ml. of concentrated ammonia solution (sp. gr. 0 88). Introduce slowly, with swirling of the contents of the flask, a solution of 50 g. of chloroacetic acid (Section 111,125) in 50 ml. of water [CAUTION do not allow chloroacetic acid to come into contact with the skin as unpleasant burns will result]. Close the flask with a solid rubber stopper and fix a thin copper wire to hold the stopper in place do not moisten the portion of the stopper in contact with the glass as this lubrication will cause the stopper to slide out of the flask. Allow the flask to stand for 24-48 hours at room temperature. Transfer the mixture to a distilling flask and distil in a closed apparatus until the volume is reduced to 100-110 ml. A convenient arrangement is to insert a drawn-out capillary tube into the flask, attach a Liebig s condenser, the lower end of which fits into a filter flask (compare Fig.//, 1) and connect the 

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XVfH glycine [2 aminoacetic acid] jl-alanine [3-3minopropanoic acid] 4-aminobtJtanoic add... 

Glycine (2-aminoacetic acid), L-serine [(S)-2-amino-3-hydroxypropionic acid] and L-alanine [(S)-2-aminopropionic acid] are simple -amino acids. The secondary products derived... 

It undergoes double decomposition reactions in solution with a number of metal salts. It reacts with glyoxal producting glycine (aminoacetic acid)... 

Dissolve 7.50 g glycine (aminoacetic acid, glycocoll) in 500 ml ddH20. Adjust the wanted pH by using 0.1 N hydrochloride acid, then fill up to 1000 ml. 

Dinitrobenzoates. The following experimental details are for glycine (aminoacetic acid) and may be easily adapted for any other amino acid. Dissolve 0-75 g. of glycine in 20 ml. of N sodium hydroxide solution and add 2 32 g. of finely powdered 3 5-dinitrobenzoyl chloride. Shake the mixture vigorously in a stoppered test-tube the acid chloride soon dissolves. Continue the shaking for 2 minutes, filter (if necessary) and acidify with dilute hydrochloric acid to Congo red. Recrystallise the derivative immediately from water or 50 per cent, alcohol. 

The following experimental details are for glycine (aminoacetic acid) and may be easily adapted for any other amino acid. Dissolve 0.75 g of glycine in 20 ml of... 

Proteins are natural polymers composed of a-amino acids linked by amide (peptide) bonds. Except for glycine (aminoacetic acid), protein-derived amino acids are chiral and have the L configuration. Table 17.1 lists the names, one- and three-letter abbreviations, and structures of the 20 common amino acids. Of these, eight (the essential amino acids) cannot be synthesized in the bodies of adult humans and must be ingested in food. 

The Gabriel-malonic ester synthesis begins with (V-phthalimidomalonic ester. Think of (V-phthalimidomalonic ester as a molecule of glycine (aminoacetic acid) with the amino group protected as an amide (a phthalimide in this case) to keep it from acting as a nucleophile. The acid is protected as an ethyl ester, and the a position is further activated by the additional (temporary) ester group of diethyl malonate. 

Glycine (aminoacetic acid, aminoethanoic acid) is HjN. CHj.COOH, with = 2.4. It is transaminated by an ala-nine-glyoxylate aminotransferase. The glycine can then be incorporated into proteins and used for serine synthesis or simply be degraded. 

Glycine (aminoacetic acid) catalogue number G7126 Sigma (Milan, Italy). 

Glycine (aminoacetic acid) is the simplest of the amino acids. Because of the many metabolic pathways in which it is found, its central inhibitory neurotransmitter properties went unrecognized until its spinal cord distribution was examined. The convulsant alkaloid strychnine is believed to block postsynaptic glycine receptors. Presynaptic release impairment may also be part of its action. While the peripheral chemical reactions of glycine are reasonably well known, its conversion to pyruvate via serine—the biochemistry of gly in central neuronal fibers—is still not fully understood. High-affinity uptake systems for gly (and several other transmitter amino acids) were soon demonstrated in CNS tissue. Serine, of course, acts as a precursor to gly. Whether it also has inhibitory neurotransmitter properties is in doubt. 

Glycine, aminoacetic acid Alanine, a-aminopropionic acid... 

Group I, Nonpolar Side Chains. Glycine (aminoacetic acid) is the simplest amino acid and the only one lacking an asymmetric C atom. 

We will discuss m-aminophenol (7-i) as an example of an ordinary amphoteric substance, and glycine (aminoacetic acid) (7-ij as an example of a zwitterion. 

Xmino-benzol, n. aminobenzene, aniline, -essig-siure,/. aminoacetic acid, glycine, -kohlen-saure, /. amidocarbonic acid, carbamic acid, sfiure, /. amino acid, -saurerest, m. amino acid residue, -verbindung, /. amino compound. -zucker, m. amino sugar. 

Glycine (Gly or G) (aminoacetic acid, aminoethanoic acid) is a nonpolar, neutral, aliphatic amino acid with the formula HOOCCH(NH2)H. Gly is the simplest amino acid and plays important roles in peptide and protein chains. It does not contain a side chain and can thus fit into secondary structures where larger amino acids cannot. Gly acts as a transmitter in the CNS where it accomplishes several functions. Gly is a precursor of porphyrins. Gly, Pro, aspartate, Ser, and Asn enable reverse turns. The acylated amino group of Gly can accept a second acyl group to give rise to a diacylamide. ... 

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