Glycans alterations

Metabolically Engineered Glycans Alter the Chemical Properties of the Cell Surface... 

Gawlitzek M, Valley U, Wagner R (2000), Ammonium alters N-glycan structures of recombinant TNFR-IgG degradative versus biosynthetic mechanisms. Biotechnol. Bioeng. 68 637-646. 

McClain DA, Lubas WA, Cooksey RC, Hazel M, Parker GJ, Love DC, Hanover JA. Altered glycan-dependent signaling induces insuhn resistance and hyperleptinemia. Proc. Natl. Acad. Sci. U.S.A. 2002 99 10695-10699. 

Freeze HH, Aebi M. Altered glycan structures the molecular basis of congenital disorders of glycosylation. Curr. Opin. Struct. Biol. 2005 15 490-498. 

Elaboration of N-linked glycans can be dramatically altered by GlcNAcT-III activity. GlcNAcT-III adds GlcNAc to the pi-4-linked mannose. This pi-4-linked GlcNAc is also referred to as the bisecting GlcNAc (Fig. 4B, g). Unlike other... 

Skrincosky D, Kain R, El-Battari A, Exner M, Kerjaschki D, Fukuda M. Altered Golgi localization of core 2 fl-l,6-Al-acetyl-glucosaminyltransferase leads to decreased synthesis of branched 0-glycans. J. Biol. Chem. 1997 272(36) 22695-22702. 

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