Glutathione naturally occurring

Cysteine [52-90 ] is a thiol-bearing amino acid which is readily isolated from the hydrolysis of protein. There ate only small amounts of cysteine and its disulfide, cystine, in living tissue (7). Glutathione [70-18-8] contains a mercaptomethyl group, HSCH2, and is a commonly found tripeptide in plants and animals. Coenzyme A [85-61-0] is another naturally occurring thiol that plays a central role in the synthesis and degradation of fatty acids. 

Kassahun K, Davis M, Hu P, Martin B, Baillie T. (1997) Biotransformation of the naturally occurring isothiocyante sulforaphane in the rat Identification of phase I metabolities and glutathione conjugates. Chem Res Toxicol 10 1228-1233. 

Sulfur nucleophiles such as thiolate anion generally appear near the top of the nucleophi-licity scale and thus readily attack oxepins (Scheme 20). While adduct formation between oxepin (7) and thiols occurs spontaneously upon mixing (74JA6929), a similar reaction between the naturally occurring tripeptide thiol, glutathione, and oxepin-arene oxide intermediates formed during mammalian metabolism is catalyzed by a glutathione epoxide transferase. 

Dynamic Docking Study of the Binding of l-Chloro-2,4-Dinitrobenzene in the Putative Electrophile Binding Site of Naturally Occurring Human Glutathione S-Transferase pi Allelo-Polymorphic Proteins... 

The amino acids believed to be involved in GTF are the constituents of the naturally occurring tripeptide glutathione (256). Anderson et al. have reported a complex of glutathione/nicotinic acid and chromium(III) to be particularly active in their in vitro assay.1198 The complex was described as being purified by HPLC, but the details of the preparation are not available. 

Wallig, M. A., A. M. Kore, J. Crawshaw, and E. H. Jeffery. 1992. Separation of the toxic and glutathione enhancing effects of the naturally occurring nitrile, cyanohydroxybutene. Fundamental and Applied Toxicology 19 598-606. 

Pickering, J.W., S.H. Wender, and E.C. Smith The effect of certain naturally occurring componnds on the activity of rat lung glncose-6-phosphate dehydrogenase, glutathione reductase and glntathione peroxidase Tob. Sci. 19 (1975) 75-76. 

Small peptides play many roles in organisms. Some, such as oxytocin and vasopressin, are important hormones. Others, like glutathione, regulate oxidation—reduction reactions. Still others, such as enkephalins, are naturally occurring painkillers. 

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