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Glutathione-Dependent Cellular Defense Systems

GLUTATHIONE-DEPENDENT CELLULAR DEFENSE SYSTEMS 18.5.1 Glutathione-Dependent Protection... [Pg.343]

Several enzyme systems exist as cellular defense (detoxification) pathways against the chemically reactive metabolites generated by GYP metabolism (91,92,102,103). These include GST, epoxide hydrolase, and quinone reductase, as well as catalase, glutathione peroxidase, and superoxide dismutase, which detoxify the peroxide and superoxide by-products of metabolism. The efficiency of the bioinactivation process is dependent on the inherent chemical reactivity of the electrophilic intermediate, its affinity and selectivity of the reactive metabolite for the bioinactivation enzymes, the tissue expression of these enzymes, and the rapid upregulation of these enzymes and cofactors mediated by the cellular sensors of chemical stress. The reactive metabolites that can evade these defense systems may damage target proteins and nucleic acids by either oxidation or covalent modification. [Pg.490]

See other pages where Glutathione-Dependent Cellular Defense Systems is mentioned: [Pg.343]    [Pg.345]    [Pg.347]    [Pg.349]    [Pg.351]    [Pg.353]    [Pg.343]    [Pg.345]    [Pg.347]    [Pg.349]    [Pg.351]    [Pg.353]    [Pg.340]    [Pg.169]    [Pg.69]    [Pg.268]    [Pg.148]    [Pg.913]    [Pg.228]    [Pg.3619]   


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