Glutathione conjugation plant metabolism

Plant. Metabolizes in plants forming water soluble, polar, nonvolatile products (Hartley and Kidd, 1987) and glutathione conjugates (Breaux et al., 1987). 

Figure 7.2 Metabolism of atrazine in sugarcane plants by (a) ALdcal kylation of the side chains, (b) hydrolysis of the 2-chloro group followed by JV-dealkylation, and (c) displacement of the 2-chloro by glutathione conjugation (Larson and Ash, 1993).

Plants. Metabolism involves dechlorination and conjugation to glutathione-5-transferases, followed by further degradation to polar, water soluble, nonvolatile metabolites... 

High rate of barban caused a significant reduction in root fw. J The metabolism of all of these chemicals except R-25788, is known to involve conjugation with glutathione in plants (18). 

Propachlor Is metabolized by this route In both a resistant and a susceptible species (Equation 16). Glutathione conjugation of propachlor occurs very rapidly Un vitro in the absence of GST enzymes (78) and It Is not clear whether differences In GSH and/or GST concentratlois influence the selectivity of propachlor and related herbicides. The concentration of GSH In higher plants Is estimated... 

Many of the metabolic transformations for pesticide detoxification that occur in plants are also found in prokaryotes, especially co-metabolic transformations. Glutathione conjugation of the chloroacteamide herbicides is observed in many species of gram negative bacteria including Pseudomonas sp and various members of the Enterobacteriaceae (57). Most of the degradative steps for FE metabolism in plants (de-esterification to F, and subsequent... 

The third metabolic pathway discovered for degradation of triazine herbicides in plants was first reported by Shimabukuro et al. (1970) and involved conjugation of atrazine with glutathione in corn nutrient uptake, excised leaves, and leaf disc experiments. This new degradation mechanism was postulated to be the primary factor in the... 

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