Glutathione conjugates spectrometry

Baillie, T.A. and Davis, M.R. 1993. Mass spectrometry in the analysis of glutathione conjugates. Biol. 

Dieckhaus, C.M. et al. 2005. Negative ion tandem mass spectrometry for the detection of glutathione conjugates. Chem. Res. Toxicol. 18 630. 

Bean, M. F., Pallante-Morell, S. L., Dulik, D. M., and Fenselau, C. (1990). Protocol for liquid chromatography/mass spectrometry of glutathione conjugates using postcolumn solvent modification. Anal. Chem. 62 121-124. 

Haroldsen, P. E., Reilly, M. H., Hughes, H., Gaskell, S. J., and Porter, C. J. (1988). Characterization of glutathione conjugates by fast atom bombardment/tandem mass spectrometry. Biomed. Environ. Mass. Spectrom. 15 615-621. 

Pearson PG, Threadgill MD, Howald WN, Baillie TA. Applications of tandem mass spectrometry to the characterization of derivatized glutathione conjugates Studies with. S -(7V-methylcarbamoyl)glutathione, a metabolite of the antineoplastic agent A-methylformamide. Biomed Envir Mass Spectrom 1988 16 51-6. 

In recent years, several techniques have been developed for mass spectrometry, whereby samples are ionized and analysed from a condensed phase, without prior volatilization. These desorption techniques have permitted the extension of mass spectrometric analyses to sulfate and glutathione conjugates, as well as to underivatized and labile glucuronic acid conjugates. Primary among these techniques are field desorption 6, plasma desorption (7), laser desorption (8), fast atom bombardment (or secondary ion mass spectrometry with a liquid sample matrix) ( ) and thermospray ionization ( O). The latter can also serve to couple high pressure liquid chromatography and mass spectrometry for analysis of involatile and thermally labile samples. 

L Jin, MR Davis, P Hu, TA Baillie. Identification of novel glutathione conjugates of disulfiram and diethyldithiocarbamate in rat bile by liquid chromatography-tandem mass spectrometry. Evidence for metabohc activation of disulfiram in vivo. Chem Res Toxicol 7 526, 1994. 

Loughlin AF, Skiles GL, Alberts DW, Schaefer WH. An ion exchange liquid chromatography/mass spectrometry method for the determination of reduced and oxidized glutathione and glutathione conjugates in hepatocytes. J Pharm Biomed Anal 2001 26 131-142. 

Mahajan MK, Evans CA. Dual negative precursor ion scan approach for rapid detection of glutathione conjugates using liquid chromatography/tandem mass spectrometry. 2008 i apW Commun Mass Spectrom 22 1032—1040. 

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