Glutarates dimethyl 3-amino

Reaction of A-protected diethyl aspartate (130) or glutamate (131) with lithium trialkylphosphonoacetate in the presence of DIBALH leads to selective formation of the A-protected y-amino-a,P-unsaturated dicarboxylates (132) as the major product. 3-(Phosphonomethyl)cyclo-pentenones (133) and -hexenones (134) are the products of the reaction of dimethyl succinate and dimethyl glutarate, respectively, with excess dimethyl (lithiomethyl)phosphonate presumably via two phosphonomethylations followed by an intramolecular olefmation. Examples of the many phosphonate olefmation reactions carried out include the synthesis of (2E, 4Z)-4-aminoalkadienoates (135), 2-aryloxy-3-phenylpropenoates (136), and isoxazoles (137). ... 

Potassium dimethyidithiocarbamate biocide, swimming pools 1 -Bromo-3-chloro-5,5-dimethyl hydantoin biocide, textile dyeing Cetalkonium chloride biocide, textile processing solutions 2[(-Hydroxymethyl) amino] ethanol biocide, textile spinning Sodium o-phenylphenate biocide, textile treatments Octadecyidimethyl [3-(trimethoxysilyl) propyl] ammonium chloride biocide, textiles Tributyltin oxide biocide, timber Sodium o-phenylphenate biocide, timber preservation Methylenebis (thiocyanate) biocide, veterinary fields Succinaldehyde biocide, veterinary preps. Tetramethylolacetylene diurea biocide, vinyl acetate latex emulsions Sodium pyrithione biocide, water cooling towers Glutaral... 

Diacetylene fatty acids were purchased from GFS. N-(2-Hydroxyethyl)-10,12-pentacosadiynamide (10) was synthesized by literatnre methods (77). 1-Amino-10,12-pentacosadiyne (11) was synthesized in fom steps from 10,12-pentacosadiynoic acid the acid in anhydrous tetrahydrofuran (THF) at 0 °C was reduced to the alcohol through treatment with hthinm alnminnm hydride (LAH, 2.5 equivalents) in diethyl ether for two hours, the alcohol was then converted to the mesylate by treatment with mesyl chloride (6 eqnivalents) in methylene chloride with diisopropyl ethyl amine over 30 minntes, the mesylate was displaced by sodium azide (1.5 equivalents) in dimethyl formamide (DMF) at 70 °C over one hour and the azide, in THF, was reduced to the amine with LAH (2 equivalents) in diethyl ether at 0 °C over one hour. N-(10,12-pentacosadiynyl)-glutamic acid (12) was prepared from 11 as follows 11 was reacted with glutaric anhydride (2 equivalents) in DMF, in the presence of diisopropylethylamine (3 equivalents), at 70 °C for 1 hour and the crade product recrystallized from a mixture of chloroform and hexanes. The identity of products were confirmed by H and C NMR. 

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