Glutamine biochemical structure

Some Compounds Structurally Related to Glutamic Acid. Their Application in Microbiological Determination of Small Quantities of Glutamine. Biochem. J. 42, 485 (1948). 

This section summarizes recent data obtained from biophysical techniques on the nature of the metal ion, catalytic, and modifier sites of E. coli glutamine synthetase. Distance relationships between these sites are given in Fig. 27. This enzyme has many diverse modes of biochemical control. Recent data presented in this review demonstrate that progress is being made toward understanding the structural basis for the control of enzymic catalysis. When x-ray data become available 127), the amino acid groups at the catalytic site will be known and will provide further details concerning the mechanism of the enzymic reaction. 

Butterfield DA, Drake J, Pocemich C, Castegna A (2001) Evidence of oxidative damage in Alzheimer s disease brain central role for amyloid beta-peptide. Trends Mol Med 7 548-554 Butterfield DA, Hensley K, Htirris M, Mattson M, Carney J (1994) beta-Amyloid peptide free radical fragments initiate synaptosomal Upoperoxidation in a sequence-specific fashion impUcations to Alzheimer s disease. Biochem Biophys Res Commun 2(X) 710-715 Butterfield DA, Hensley K, Cole P, Subramaniam R, Aksenov M, Aksenova M, Bummer PM, Haley BE, Carney JM (1997) Oxidatively-induced structural alteration of glutamine synthetase assessed by analysis of spin labeled incorporation kinetics relevance to Alzheimer s disease. J Neurochem 68 2451-2457... 

Adam, A., M. Dews, V. Souvannavong, P. Lefrancier, J. Choay, and E. Lederer Correlation of structure and adjuvant activity of N-acetyl-muramyl-L-alanyl-D-iso-glutamine (MDP), its derivatives and analogues. Anti-adjuvant and competition properties of stereoisomers. Biochem. Biophys. Res. Comm. 72, 339 (1976). 

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