Glutamate transporter expression

Rothstein, J. D., Patel, S., Regan, M. R. etal. Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433 73-77,2005. 

Very recently, (3-lactam antibiotics have been shown to offer neuroprotection by increasing glutamate transporters expression via gene activation [15] in addition, the discoveries of new biologically active (3-lactams such as cholesterol acyl transferase inhibitors [16-18], thrombin inhibitors [19], human cytomegalovirus protease inhibitors [20], matrix-metallo protease inhibitors [21], inhibitors of human leukocyte elastase (HLE) [22, 23] and cysteine protease [24, 25], and apoptosis inductors [26, 27] have provided much needed motivation for continuous development of new (3-lactam systems. 

Voutsinos-Porche B., Koning E., Clement Y., Kaplan H., Ferrandon A., Motte J., and Nehlig A. (2006). EAAC1 glutamate transporter expression in the rat lithium-pilocarpine model of temporal lobe epilepsy. J. Cereb. Blood Flow Metab 26 1419-1430. 

Gras C, Herzog E, Bellenchi GC, Bernard V, Ravassard P, Pohl M, Gasnier B, Giros B, El Mestikawy S (2002) A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons. J Neurosci 22 5442-5451. 

Suarez, I., Bodega, G., Rubio, M., Fernandez-Ruiz, J. J., Ramos, J. A., and Fernandez, B. (2004b). Prenatal cannabinoid exposure down-regulates glutamate transporter expressions (GLAST and EAAC1) in the rat cerebellum. Dev. Murosci. 26, 45—53. 

Rauen, T. (2000). Diversity of glutamate transporter expression and function in the mammalian retina. Amino Acids 19, 53-62. 

Berger UV, Hediger MA (1998) Comparative analysis of glutamate transporter expression in rat brain using differential double in situ hybridization. Anat Embryol 798 13-30. 

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