Glutamate receptor competitive NMDA

Memantine is a non-competitive antagonist oftheN-methyl-D-aspartate (NMDA) type of glutamate receptors, which are located ubiquitously throughout the brain. It regulates activity... 

A post-mortem study on the brains of alcohoUcs showed a modest increased binding for [3H]glutamate and [3H]CGP-39653—a competitive NMDA receptor antagonist (Freund and Anderson 1996). In humans with a history of alcohol abuse, an increase in immunoreactivity toward AMPA GluR2 and GluR3 subunits was also found (Breese et al. 1995). In rodents lacking functional... 

Carboni S., Melis F., Pani L., Hadjiconstantinou M., and Rossetti Z. L. (1990). The non-competitive NMDA-receptor antagonist MK-801 prevents the massive release of glutamate and aspartate from rat striatum induced by l-methyl-4-phenylpyridinium (MPP+). Neurosci. Lett. 117 129-133. 

Memantine is a competitive inhibitor of the A/-methyltaspar-tate glutamate receptor (NMDA). Clinically, memantine has been effective in the treatment of Alzheimer s dementia and... 

APV (2-amino-5-phosphonopentanoic acid) is a competitive (NMDA) GLUTAMATE RECEPTOR ANTAGONIST which has anticonvulsant/antiepileptic actions. It is used as a pharmacological tool. 

The NMDA receptor has received considerable attention, largely because of the early development of selective tools for its study. NMDA itself is a specific ligand for this receptor with little action at other types of glutamate receptor. In particular, the discovery of a highly selective and competitive NMDA antagonist... 

---