Glutamate receptor agonists antagonists

Flood JF, Baker ML, Davis JL Modulation of memory processing by glutamic receptor agonists and antagonists. Brain Res 521 197-202, 1990 Flood JF, Morley JE, Roberts E Memory-enhancing effects in male mice of pregnenolone and steroids metabohcally derived from it. Proc Natl Acad Sci U S A 89 1567-1571, 1992... 

Additional 2-aminoindane derivatives, (I), effective as metabotropic glutamate receptor agonists or antagonists were prepared by the author (3) in an earlier investigation. 

Cubane derivatives, (IV), prepared by Pajouhesh (6) were effective as metabotropic glutamate receptor agonists or antagonists and used in treating neurological disorders. 

L-Glutamate acts as an excitatory neurotransmitter at many synapses in the mammalian central nervous system. Electrophysiological measurements and the use of various selective agonists and antagonists indicate that different glutamate receptors co-exist on many neurons. 

These X-ray structures provide a wealth of information about the interactions of agonists, antagonists, and allosteric modulators with the glutamate receptor subunit... 

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