Glutamate, enzyme activity

Increased serum glutamic oxaloacetic transaminase enzyme activity Increased blood pressure increased hemoglobin... 

Dale, L. B., Babwah, A. V., and Ferguson, S. S. (2001) Mechanisms of metabotropic glutamate receptor desensitization role in the patterning of effector enzyme activation. Neurochem. Int. 41, 319-326. 

As shown in Fig. 3, Lewis acids (i.e., metal ions and hydrogen bond donors) display syn or anti stereochemistry as they interact with the carboxylate anion. However, in a study of enzyme active sites. Candour (1981) first noticed that hydrogen bond donors to the carboxylates of aspartate and glutamate residues preferentially occur with syn stereochemistry. As a carboxylate-hydrogen bond donor interaction COg-H... 

Additional information <2, 3> (<2> the concentration of glutamate which yields half-maximal activity is 33 mM for y-glutamyl kinase DHPr, and 37mM for y-glutamyl kinase w-l-, no typical Michealis-menten kinetics [2] <3> plots of the enzyme activity as a function of ATP concentration are non-hyperbolic [5]) [2, 5]... 

A closely related E. coli protein is a 79-kDa multifunctional enzyme that catalyzes four different reactions of fatty acid oxidation (Chapter 17). The amino-terminal region contains the enoyl hydratase activity.32 A quite different enzyme catalyzes dehydration of thioesters of (3-hydroxyacids such as 3-hydroxydecanoyl-acyl carrier protein (see Eq. 21-2) to both form and isomerize enoyl-ACP derivatives during synthesis of unsaturated fatty acids by E. coli. Again, a glutamate side chain is the catalytic base but an imidazole group of histidine has also been implicated.33 This enzyme is inhibited irreversibly by the N-acetylcysteamine thioester of 3-decynoic acids (Eq. 13-8). This was one of the first enzyme-activated inhibitors to be studied.34... 

Bacich D. J., Ramadan E., O Keefe D. S., Bukhari N., Wegorzewska I., Ojeifo O., Olszewski R., Wrenn C. C., Bzdega T., Wroblewska B., Heston W. D., and Neale J. H. (2002). Deletion ofthe glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate. J. Neurochem. 83 20-29. 

Table 5.1 Stimulatory effect of glutamate-mediated Ca2+ influx on enzymic activities involved in excitotoxicity...

Enzymic activities were determined by procedures described earlier (Farooqui et al., 1993). Specific activity was expressed as nmol/min/mg protein. Results are the means SEM for three different cultures. Glu, glutamate and Dextror, Dextrorphan. 

Table 6.2 Alterations in enzymic activities of brain tissue induced by glutamate and its analogs...

---