Glutamate-cysteine ligase modifier

Nakamura S, Kugiyama K, Sugiyama S, Miyamoto S, Koide S, et al. 2002. Polymorphism in the S -flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction. Circulation 105 ... 

Tosic M, et al. 2006. Schizophrenia and oxidative stress Glutamate cysteine ligase modifier as a susceptibility gene. Am J Hum Genet 79 586-592. 

Yang Y, Dieter MZ, Chen Y, Shertzer HG, Nebert DW, et al. 2002. Initial characterization of the glutamate-cysteine ligase modifier subunit GCLM(—/—) knockout mouse. J Biol Chem 277 49446-49452. 

Chen Y, Shertzer HG, Schneider SN, Nebert DW, Dalton TP. 2005. Glutamate cysteine ligase catalysis Dependence on ATP and modifier subunit for regulation of tissue glutathione levels. J Biol Chem 280 33766-33774. 

Notes Values are IC50 (pAf) in the MTT cytotoxicity assay. Neurons from Gdm (-/-) mice, which lack the modifier subunit of glutamate cysteine ligase have very low glutathione levels. DMNQ = dimethoxy-l,4-naphtoquinone. Source Giordano and Costa (unpublished results). 

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