Glucose transport into cell

It stimulates synthesis of glycogen, fat, and protein. It inhibits breakdown of glycogen, fat, and protein. It increases glucose transport into cells. 

Glucose transport into cell provides glycerol phosphate to permit esterification of fatty acids supplied by lipoprotein transport... 

Decreased gluconeogenesis Increased glucose transport into cells Induction of lipoprotein lipase Stimulation of glycogenolysis... 

Muscle T glucose transport into cell T glycogenesis T protein and triglyceride synthesis... 

Not only have animals or isolated organs of animals been used to perform pharmacological studies, but also cells in culture. In a study done by Prof. Yamasaki25 at the University of Hiroshima (Figure 16.28), Ehrlich ascites tumor cells have been used to demonstrate the increase of glucose transport into the cell as a function of G115. 

Transport into Cells Can Limit Glucose Utilization... 

Choose the ONE correct answer 23.1 In which one of the following tissues is glucose transport into the cell enhanced by insulin A. Brain B. Lens C. Red blood cells D. Adipose tissue E. Liver Correct answer = D. The major tissues in which glucose transport requires insulin are muscle and adipose tissue. The metabolism of the liver responds to insulin, but hepatic glucose transport is rapid and does not require insulin. 

Glucose transport into skeletal muscle cells via insulin-dependent glucose transport proteins in the plasma membrane (see p. 95) and subsequent glucose metabolism are depressed because of low levels of circulating insulin. 

Predict the effects of the following on the initial rate of glucose transport into vesicles derived from animal cells that accumulate this sugar by means of Na+ symport. Assume that initially A P = 0, ApH = 0 (pH = 7), and the outside medium contains 0.2MNa+, whereas the vesicle interior contains an equivalent amount of K+. 

Glucose transport into intestinal epithlial cells... 

Patients with type 2 diabetes have often an increased HGO [110-112]. As the glycogenolysis is decreased [111] and in all cases transient, the cause of augmented HGO is increased gluconeogenesis, mainly from lactate [111, 113]. The increased lactate production is interesting. To give a constant overproduction of lactate, glucose must be transported into cells but not oxidized, mainly because there is an increased level of FFA and therefore an increased fat oxidation [74]. The overproduction is thus caused by a mismatch between the fluxes of glucose and fat. 

Predict the effects of (a) valinomycin and (b) gramicidin A on the initial rate of glucose transport into vesicles derived from cells that accumulate glucose by cotransport with Na+. Assume that the outside medium contains 0.2 Af Na+ and that the interior of the vesicle contains an equivalent concentration... 

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