Glucose homeostatic mechanisms

Inhibition of drug-metabolizing enzymes —Displacement of drug from protein-binding sites —Impairment of glucose homeostatic mechanism —Induction of metabolizing enzymes Increased insulin resistance —Reduced renal secretion —Unknown... 

SYMPATHOMIMETICS-EPINEPHRINE ANTIDIABETIC DRUGS May t antidiabetic therapy requirement Epinephrine causes the release of glucose from the liver and is an important defence/homeostatic mechanism. Hyperglycaemia may occur due to an antagonistic effect Larger doses of antidiabetic therapy may be needed during the period of epinephrine use, which is usually in the short term or in emergency situations... 

Hypoglycaemia, especially with nonselective members, which block p -receptors, and especially in diabetes and after substantial exercise, due to impairment of the normal sympathetic-mediated homeostatic mechanism for maintaining the blood glucose, i.e. recovery from iatrogenic hypoglycaemia is... 

Figure 36-2. The metabolic flow following a postfeeding fast. Blood glucose levels begin to decrease, triggering homeostatic mechanisms to prevent it from decreasing dramatically.

These results outline the sophisticated survival responses induced by bacteria when they are subjected to deleterious changes of pH, temperature, or osmotic pressure. Under stress, the bacterial defense mechanisms are tightly coupled to the cell s metabolism and homeostatic mechanisms. When stimulating the metabolism of S. aureus with D-(+)-glucose in the presence of highly concentrated salts, a significant current response is measured by SECM in spite of the low cytoplasmic membrane permeability to hydrophilic mediators, such as ferricyanide. One explanation for the presence of this current enhancement implies that the bacteria to survive the osmotic stress, changes the cytoplasmic membrane structure or membrane-associated protein profile to promote ferrocya-nide production. 

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