Glucose analog inhibitors

Keywords Glycogen phosphorylase Glucose Glucose analog inhibitors NIDDM Sugar-derived heterocycles... 

The recent advances, especially during last few years, in different heterocyclic glucose analog inhibitors (GAIs) and their precursors are briefly discussed in this chapter, including their biological activities against this very important enzyme GP, from different perspectives. 

Uridine - 5 - diphosphate glucose analogs Inhibitors of protein glycosation that shows antiviral activity... 

Nine other glucose analogs were systematically studied with yeast and mammalian brain hexoklnases (79). Five of these analogs exhibited substrate activity with the yeast isoenzyme, and two were found to be competitive inhibitors. Two of the alternate substrates were studied with the mammalian enzyme, but no significant differences were found. 

Catalytic site, which binds substrates GIP and glycogen, and the inhibitor glucose and glucose analogs (GA)... 

The substrate specificities of both mammalian and yeast hexo-kinases have been extensively studied (76,77). Nevertheless, work in this area continues both in the search for isoenzyme specific inhibitors and in increasingly detailed investigations of the catalytic mechanism. Recently potential transition state analogs PI-(adenosine-5 )-P3-glucose-6 triphosphate (Ap -glucose) and P1-(adenosine-5 )-P4-glucose-6 triphosphate (Ap.-giucose) were tested as inhibitors of four hexokinase isoenzymes. However, they were found to exhibit less affinity for the enzyme than either of the natural substrates alone (78). 

---