Glucosaminic acid periodate oxidation

Besides amino acids, labeled saa harides are suitable for the labeling of glycoproteins. In this manner, glycoproteins have been labeled with H-mannose H-glucosamine N-acetylmanosamine Saccharides may also be allowed to react with proteins after periodate oxidation... 

During the elucidation of the structure of mannosidostreptomycin by methylation. Fried and Stavely isolated two derivatives of a dimethyl ether of iV-methyl-L-glucosamine. In order to compare their physical constants with those of a known compound in the n-series. Fried and Walz prepared derivatives of 2-deoxy-3,6-di-0-methyl-2-methylamino-n-glucose. The addition of methylamine and hydrogen cyanide to 2,5-di-0-methyl-D-arabinose (prepared by the periodate oxidation of 3,6-di-O-methyl-D-glucose) was followed by hydrolysis, and jdelded a mixture of a dextro- and a levo-rotatory acid. The dextrorotatory product was con-... 

In a study of the oxidation of 2-amino-2-deoxy-D-glucose (D-glucosamine) derivatives, Neuberger12 obtained better results using sodium metaperiodate (at its accompanying pH of 3 to 4) than with periodic acid at lower pH values and a pH of 4.5 was found by Jeanloz and Forchielli78a to be optimal for these derivatives. 

Action of dilute sulfuric acid for a short period of time afforded a crystalline disaccharide (Vb), in a 20 to 30 % yield. It contained equal amounts of d-glucosamine and D-glucuronic add, and a free amino group. Esterification of the carboxyl group, followed by oxidation with mercuric oxide, gave the... 

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