Glucokinase allosteric

Different responses of isozymes to allosteric modulators. This difference is useful in fine-tuning metabolic rates. Hexokinase IV (glucokinase) of liver and the hexokinase isozymes of other tissues differ in their sensitivity to inhibition by glucose 6-phosphate. 

Allosteric Activators of Glucokinase (GK) for the Treatment of Type 2 Diabetes... 

Figure 8.2 Co-crystal structure of the GK activator 8.20 bound in the allosteric site of glucokinase (pdb code 1V4S). Key residues from the mutation studies are highlighted.

M. Larion and B. G. Miller, Homotropic Allosteric Regulation in Monomeric Mammalian Glucokinase , Arch. Biochem. Biophys., [online computer file], 2012, 519, 103. 

In the search of novel allosteric glucokinase activators, a docking approach into the enzyme structure generated satisfactory actives only after a refined similarity model against four different known activators was used (Scheme 5.10)... 

Tajima, N Yamashita, T Vitt, D., and Noda, H. (2011) Discovery and hit-to-lead optimization of novel allosteric glucokinase activators. Bioorganic and Medicinal Chemistry Letters, 21, 5417-5422. 

---