Glucoheptonates

Sodium glucaspaldrate Sodium glucoheptonate Sodium monochloracetate Sodium m-nitrobenzene 600 600 550 ... 

Chemical Name Erythromycin glucoheptonic acid salt Common Name —... 

A solution of 10 grams of d-glucoheptonic acid lactone in 50 ml of distilled water is warmed on a steam bath for about 2 hours to hydrolyze the lactone to the acid. The mixture is cooled and 100 ml of 95% ethanol are added. To the solution of glucoheptonic acid are added about 37 grams of erythromycin and the volume of the reaction mixture is brought to 200 ml by the addition of 95% ethanol. The reaction mixture is stirred for about 2 hours and is filtered through a porcelain filter candle of porosity 02. To provide a steriie product, aseptic technique is used throughout the remainder of the procedure. 

To the fiitered solution are added slowly and with stirring about 1,200 ml of anhydrous ether, to cause precipitation of erythromycin d-glucoheptonate and to keep In solution any excess of unreacted erythromycin. The precipitated erythromycin salt is removed by filtration through a sintered glass funnel, is washed with anhydrous ether and is dried in vacuo. Erythromycin d-glucoheptonate melts over a range of about 95° to 140°C. 

Hydroxycarbonic adds, such as dtric, tartaric, malic, and hydroxyisobutyric acid, but also gluconate or glucoheptonate, are assumed to form the same kind of complex as the polyols do [23,28,29]. 

Tc(V) gluconate and glucoheptonate are often used when the reaction should be carried out in a neutral aqueous- or mixed aqueous/organic medium, and a rapid exchange reaction and high radiochemical purity of the product is required. In radiopharmaceutical preparations, Tc(V) tartrate is also quite often used. For labelling modified antibodies Tc(V) tricine has recently been particularly recommended [33],... 

The need to achieve high yield in one-pot synthesis, coupled to the relative kinetic inertness of rhenium complex (e.g. compared to technetium) and the mild conditions required has led to the development of useful versatile rhenium(V) intermediates that can be quickly prepared in quantitative yield, and are metastable, i.e. kinetically labile enough to react rapidly with the final chelator, again in high yield. The most widely used ligands suitable for this purpose are polydentate hydroxycarboxylic acids such as glucoheptonate [116a], citrate (47), tartrate (48), and 2-hydroxyisobutyric acid (49) [159]. Examples are discussed elsewhere in this chapter. They are typically used in the presence of Sn(II) to reduce Re(VII) to Re(V), at moderately elevated temperature (50-100 °C) at pH 2-3 (acid pH promotes reduction of perrhenate, presumably by facilitat-... 

Sodium formaldehyde sulfoxylates, 23 677 Sodium glucoheptonate, 4 708 Sodium D-gluconate, 4 708... 

As early as 1917, it was known that C2 and C3 in this trimethyl sugar each carried a methoxyl group, since (a) it failed to yield an osazone, and (b) the trimethyl-D-glucoheptonic acid derived from it by a cyanohydrin synthesis gave a lactone only with the concomitant loss of one of the methyl radicals.135 The production of a dimethyl- and not a trimethyl-... 

Jaggi, M., Khar, R., Chauhan, U., and Gangal, S. Liposomes as carriers of tech-netium-99m glucoheptonate for liver imaging. Int. J. Pharm. 1991, 69, 77-79. 

The filtered and secreted marker may irreversibly bind to renal tubule, making their quantification in urine of little value. They are primarily used for static imaging of the kidneys and to obtain information about the functional renal mass. Tc-dimercaptosuccinic acid and Tc-glucoheptonate are good examples of such markers [172 -175]. 

It is now 20 years and 13 years since the first and second editions respectively of Chemical Admixtures for Concrete were published. A first glance at the international admixture business could lead to the impression that not a lot had changed in 20 years certainly not enough to justify the complete revision of the second edition of the book. While it is true that products based on lignosulfonates, sodium glucoheptonate and com symp are still provided to the market in thousands of tonnes every year, there have been several significant changes ... 

Tyrosine Cysteine-homocysteine disulfide 3-Methoxytyrosine Erythromycin glucoheptonate... 

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