Glucan from Candida albicans

Gopal P, Sullivan PA, Shepherd MG (1984) Isolation and structure of glucan from regenerating spheroplasts of Candida albicans. J Gen Microbiol 130 1217-1225... 

Papulacandin B, an antibiotic produced by the deuteromycete Papularia sphaerosperma, inhibits the growth of yeasts, but has no effect on other fungi, bacteria, or protozoa.The mode of action involves the inhibition of synthesis of alkali-insoluble jS-D-glucan of Saccharomyces cerevisiae and Candida albicans in sphaeroplasts and causes lysis of cells by osmotic rupture.Echinocandin B and a structurally related antibiotic aculeacin A also inhibit j3-D-glucan synthesis in yeast, possibly in a similar manner.Papulacandin B has been shown to inhibit the transfer of D-glucose from UDP-D-glucose, but not D-mannose from GDP-D-mannose, into dolichyl phosphate. 

N.N. Miura, Y. Adachi, T. Yadomae, ff. Tamura, S. Tanaka, N. Ohno, Structure and biological activities of P glucans from yeast and mycelia forms of Candida albicans, Microbiol. Immunol, 47 (3), 173-182,2003. 

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