Papularia sphaerosperma

Papulacandin B, an antibiotic produced by the deuteromycete Papularia sphaerosperma, inhibits the growth of yeasts, but has no effect on other fungi, bacteria, or protozoa.The mode of action involves the inhibition of synthesis of alkali-insoluble jS-D-glucan of Saccharomyces cerevisiae and Candida albicans in sphaeroplasts and causes lysis of cells by osmotic rupture.Echinocandin B and a structurally related antibiotic aculeacin A also inhibit j3-D-glucan synthesis in yeast, possibly in a similar manner.Papulacandin B has been shown to inhibit the transfer of D-glucose from UDP-D-glucose, but not D-mannose from GDP-D-mannose, into dolichyl phosphate. 

Glycoside antibiotic. Isol. from Papularia sphaerosperma. Active against yeasts. Inhibitor of glucan synthesis. Amorph. solid. Sol. MeOH, 1-propanol, Me2CO, DMF, EtOH fairly sol. EtOAc, CHCI3, CCI4 poorly sol. H2O, hexane-CeHs, EtzO. 

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