Glomerulonephritis diagnosis

Suggested Alternatives for Differential Diagnosis Acute poststreptococcal glomerulonephritis, spotted fevers, typhus, malaria, hepatitis, Colorado tick fever, septicemia, heat stroke, disseminated intravascular coagulation, leptospirosis, hemolytic uremic syndrome. 

Eike SEE, PAN has a wide range of clinical manifestations. These include fever, weight loss, severe abdominal and musculoskeletal pain, tachycardia, acute glomerulonephritis, polyneuritis, myocardial inferction, and such pulmonary manifestations as bronchial asthma. The frequency of this disease is approximately 8 per 1,000 population, but the clinical diagnosis rate is considerably lower than postmortem studies suggest. In the United States incidence is reported to range from 3 to 4.5 cases per 100,000 population per year. Renal involvement is one of the most common and devastating aspects of... 

The prevalence of systemic lupus erythematosus in the general population is 40-50 cases per 100 000 persons. Systemic lupus erythematosus has a clear female preponderance (female to male ratio is 9 1). Furthermore, systemic lupus erythematosus is more prevalent in African Americans and Asians than in Caucasians. In addition to constitutional symptoms, such as fever, weight loss, and malaise, nearly every organ system can be involved (e.g. glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and non-erosive arthritis). Owing to marked interindividual variability in the clinical expression of the disease, a list of 11 clinical criteria has been proposed, of which 4 must be satisfied for the diagnosis. 

Figure 1 (See color insert.) Patterns of pathology of WG. (A) Blue necrosis with many degenerating neutrophils characteristic of WG, a giant cell is also present (arrow) (H + E stain, x 100). (B) Capillaritis with pulmonary hemorrhage (x200) (H + E stain). (C) Vasculitis necessary for the diagnosis of WG (H + E stain, x 100). (D) Arteritis with numerous eosinophils present (eosinophilic variant) (H + E stain, x 100). (E). Biopsy of the nose showing venulitis (H + E stain, x 200). (F) Kidney biopsy showing crescentic glomerulonephritis (trichrome stain, x 100). Abbreviation H + E, hematoxylin-eosin.

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