Glomerular filtration rate estimated creatinine clearance

However, it is still debatable which method most accurately predicts individual values of glomerular filtration rate or creatinine clearance. Whereas the Cr-EDTA method is the most accurate method of estimating... 

Lenle, F, V, and Suit, P (1989). Assessment of renal function by serum creatinine and creatinine clearance Glomerular filtration rate estimated by four procedures. Our. Cfiem. 35, 2,326-2330. 

Creatinine clearance The rate at which creatinine is filtered across the glomerulus an estimate of glomerular filtration rate. 

From a scientific point of view, glomerular filtration rate (inulin or creatinine clearance) is the best global estimate of renal function. Other parameters of interest include, but are not limited to ... 

It is well known that both glomerular and tubular renal functions decline with age in at least one third of individuals. As a result there is greater variation in renal function in older subjects. Glomerular filtration rate can be predicted by creatinine clearance, which can be estimated based on measured serum creatinine (Sercr) concentration. One such formula is the Cochrane and Gault formula in which... 

Ronnhedh C, Jacquenod M, Mather LE (1996) Urineless estimation of the glomerular filtration rate and renal plasma flow in the rat. J Pharm Tox Methods 36 123-129 Sapirstein LG, Vidt DC, Mandell MJ, Hanusek G (1955) Volumes of distribution and clearances of intravenously injected creatinine in the dog. Am J Physiol 181 330-336 Sarkar SK, Holland GA, Lenkinski R et al. (1988) Renal imaging studies at 1.5 and 9.4 T effects of diuretics. Magn Reson. Med 7 117-124... 

Rohn HA, Hall PM, Wei R. Inaccuracy of estimated creatinine clearance for prediction of iothalamate glomerular filtration rate. Am J Kidney Dis 1984 9 48-54. 

IMPAIRED RENAL CLEARANCE OF DRUGS If a drug is cleared primarily by the kidney, dose modification should be considered in patients with renal dysfunction. When renal clearance is diminished, the desired effect can be maintained either by decreasing the dose or lengthening the dose interval. Estimation of the glomerular filtration rate (GFR) based on serum creatinine, ideal body weight, and age provides an approximation of the renal clearance of many drugs. 

Glomerular filtration rate (GFR) is the best global estimate of renal function. Insulin clearance is the gold standard for GFR measurement. Greatinine clearance may also be used, although its value exceeds the exact value for GFR because creatinine is not exclusively excreted by the tubules but also secreted by the tubules. This discrepancy increases as GFR falls. Serum creatinine measurement does not reflect abnormal renal function until after GFR has been reduced to at least 50% of the baseline value [6]. 

Lead nephropathy as a toxicological topic has presented various interpretive clinical and empirical dilemmas. Some appear to have resolved to some extent. Some are mainly confined to nephropathic responses per se. Some are shared with other lead-associated toxic endpoints. A classical endpoint in Pb-induced nephropathy is a reduced estimated or measured glomerular filtration rate (GFR), typically employing creatinine clearance rates, in tandem with measurements of blood urea nitrogen (BUN) and serum creatinine levels. Such declines in GFR are proportional to the level of PbB in chronic injury, subsequent to any transitory hyperfiltration. 

Urea is filtered at the glomerulus and about 40% is reabsorbed by passive diffusion from the renal tubules. Estimation of urea clearance therefore represents about 60% of the glomerular filtration rate. In most laboratories, however, creatinine clearance measurement is preferred to urea clearance. 

The anhydride of creatine is creatinine, in which form it is found in urine. Changes in the excretory function of the kidneys are reflected in plasma urea and creatinine concentrations. Glomerular filtration rate (GFR) and overall kidney function is conveniently estimated by metisuring creatinine clearance in the volume of urine excreted in 1 minute. Its value is about 125 ml/minute in healthy young men. It is usually a little less in young women and at 70 years of age it is about 75% of the value in youth. Kidney failure rarely produces symptoms until the GFR falls below 30 ml/minute. 

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