Glibenclamide Verapamil

Slc22a7) Drugs NSAIDs, AZT, MTX, zalcitabine Drugs p-lactam antibiotics, NSAIDs, bumetanide, enalapril, glibenclamide, rifampicin, verapamil... 

Oat2 Benzylpenicillin, erythromycin, tetracycline, rifampicin, glibenclamide, tolbutamide, zidovudine, ganciclovir, digoxin, enalapril, verapamil, methotrexate, acetylsalicylic add... 

Numerous pharmaceutical companies have created Pgp modulators by modifying existing drugs such as verapamil, cyclosporine A, glibenclamide, and others from certain related chemical structures. These research efforts are in various phase I, II, and III clinical studies [214]. No single chemical structure has proven to be effective in phase III studies to date. 

Only few compounds known to inhibit classical ABC transporters are specific for this type of pumps. Many (e.g. verapamil) also affect ion channels (Lee and Tsien, 1983), are not properly evaluated in plants and should therefore be used with caution. Recently, inhibition of long-distance transport of flavonoids by the sulfonylurea glibenclamide, which inhibits certain but not all MRP-type ABC transport processes on plant vacuoles (Forestier et al., 2003), was used an argument that MRP-type transporters are involved in this process (Buer et al, 2007). However, glibenclamide can also inhibit ff-dependent transport processes (Martinoia and Klein, unpublished). 

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