Glial cells high concentration

There are numerous GABAergic neuronal pathways in the CNS. y-Aminobutyric acid is found in high concentrations in the cerebellum, is also found in the hypothalamus, thalamus, and hippocampus, and occurs in low concentrations in practically all brain structures as well as in the spinal cord. The amounts present are relatively high—on a pmol/g order of magnitude— rather than the nanomolar quantities seen with most major neurotransmitters. y-Aminobutyric acid also occurs in glial cells, where its role is less well defined. 

As a quantitatively measurable specific function of glial cells, the rate of synthesis of three neurotrophic factors (nerve growth factor [NGF] brain-derived neurotrophic factor [BDNF] and glial cell line-derived neurotrophic factor [GDNF]) was measured. In the Ohta et al. (2002) study, the enhancer effect of (-)-BPAP was measured only in the high concentration range. The authors found the amount of NGF, BDNF, and GDNF secreted from astrocytes into the culture medium increased by up to 120,2, and 7 times more, respectively, than those of the control treatment with 0.35 mM (-)-BPAP for 24 h. The (-)-BPAP-... 

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