Gliadin antibodies

Osman, A.A., Uhlig, H., Thamrn, B., Schneider-Mergener, J., Mothes, T. 1998. Use of the phage display technique for detection of epitopes recognized by polyclonal rabbit gliadin antibodies. FEBS Lett 433 103-107. 

Gliadin Antibodies of CD Patients Recognize Deamidated Gliadin. 45... 

Does Epitope Specificity of Gliadin Antibodies of CD Patients Mirror... 

These features of substrate specificity of tTG are mirrored by epitope specificity of gliadin antibodies of CD patients. The common core of the nona-peptides specifically recognized by antibodies of CD patients is QPEQPFP with the amino acid proline residing in position +2 [127]. However, in accordance with results from studies of substrate specificity of tTG [182], exchange of phenylalanine residue for tyrosine completely abolished binding of IgA of CD patients [127]. 

Studies of epitope specificity of gliadin antibodies and substrate specificity of tTG point to a role of proline and phenylalanine in amino acid positions +2 and +3 in glutamine deamidation. In contrast, investigations of T-cell stimulatory peptides reveal several potent T-cell stimulatory peptides from the N-terminal part of a-type gliadin containing the PELPY motif. In this connection, it was shown that substitution of phenylalanine in the +3 position or other amino acids in the glutenin peptide Git-156 inhibited the T-cell proliferative response [186]. 

Berger E, Biirgin-Wolff A, Freudenberg E. Diagnostic value of the demonstration of gliadin antibodies in celiac disease. Klin Wochenschr 1964 42 788-790. 

Ghedira I, Sghiri R, Ayadi A, Sfar MT, Harbi A, Essoussi AS, et al. Anti endomysium, anti-reticulin and anti-gliadin antibodies, value in the diagnosis of celiac disease in the child. Pathol Biol (Paris) 2001 49 47-52. 

Devery JM, La Brooy JT, Krillis S, Davidson G, Skerritt JH. Anti-gliadin antibody specificity for gluten-derived peptides toxic to coeliac patients. Clin Exp Immunol 1989 76 384-390. 

Damage of intestinal mucosa Gliadin antibodies Autoantibodies... 

The diagnostic efficiency of autoantibody determination was found to exceed that of gliadin antibodies [117, 118]. Autoantibody tests were based mainly on the determination of IgA immunoglobulins against endomysium, human umbilical cord, and tTG. These autoantibodies were highly sensitive and specific with values for both parameters exceeding 95% in most studies [118-121],... 

In CD, autoantibody assays have generally replaced gliadin antibody assays. Measurement of gliadin antibodies is, however, advantageous in small children. Autoantibodies are often absent in CD children under 2 years of age [148, 149]. In another study, antibodies against tTG were found to develop not before an age of 1.3 years [150], Increased concentration of gliadin antibodies may be helpful in the investigation of other... 

Hill PG, Thompson SP, Holmes GKT. IgA anti-gliadin antibodies in adult celiac disease. Chn Chem 1991 37 647-50. 

Neves, M.M.P.S., Gonzdlez-Garcia, M.B., Santos-Silva, A. and Costa-Garcfa, A. (2012) Voltammetric immunosensor for the diagnosis of celiac disease based on the quantification of anti-gliadin antibodies. Sens. Actuators, B, 163, 253-259. 

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