Glia/glial cells neuron-regulating function

The disclosure of this active role of glia led to the model of the tripartite synapse (Araque et al, 1999 Bezzi and Volterra, 2001), where, besides the important tasks pursued by pre- and postsynaptic neuronal elements, a pivotal role in regulating synaptic function, strength, and plasticity is played by the glial cells surrounding the above-mentioned structures. 

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