Gilman, Alfred

Hardman, Joel Limbird, Lee and Gilman, Alfred, eds. (2002). Goodman and Gilman s The Pharmacological Basis of Therapeutics. New York McGraw-Hill. 

The family of heterotrimeric G proteins is involved in transmembrane signaling in the nervous system, with certain exceptions. The exceptions are instances of synaptic transmission mediated via receptors that contain intrinsic enzymatic activity, such as tyrosine kinase or guanylyl cyclase, or via receptors that form ion channels (see Ch. 10). Heterotrimeric G proteins were first identified, named and characterized by Alfred Gilman, Martin Rodbell and others close to 20 years ago. They consist of three distinct subunits, a, (3 and y. These proteins couple the activation of diverse types of plasmalemma receptor to a variety of intracellular processes. In fact, most types of neurotransmitter and peptide hormone receptor, as well as many cytokine and chemokine receptors, fall into a superfamily of structurally related molecules, termed G-protein-coupled receptors. These receptors are named for the role of G proteins in mediating the varied biological effects of the receptors (see Ch. 10). Consequently, numerous effector proteins are influenced by these heterotrimeric G proteins ion channels adenylyl cyclase phosphodiesterase (PDE) phosphoinositide-specific phospholipase C (PI-PLC), which catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) and phospholipase A2 (PLA2), which catalyzes the hydrolysis of membrane phospholipids to yield arachidonic acid. In addition, these G proteins have been implicated in... 

Louis Goodman and Alfred Gilman, The Pharmacological Basis of Therpeutics, The Macmillan Co., New York, N.Y., 1941. 

Alfred Gilman Professor of Pharmacology, Department of Pharmacology, Yale University School of Medicine, New Haven Mark A. Schumacher, PhD, MD... 

Jaffe, Jerome H., and William R. Martin. 1985. "Opioid Analgesics and Antagonists." In The Pharmacological Basis ofTherapeutics, edited by Alfred G. Gilman, Louis S. Goodman, Theodore W. Rail, and Fend Murad. 7th ed. New York Macmillan. 

Alfred Gilman and Martin Rodbell Ph y siology / Med icine "G-proteins"... 

PIERRE VAN DE WEGHE, Laboratoire de Chimie Organique et Bioorga-nique (CNRS UMR 7015), Ecole Nationale Superieure de Chimie de Mulhouse, 3, rue Alfred Werner, F-68093 Mulhouse-cedex, France MICHAEL S. VANNIEUWENHZE, Department of Chemistry and Biochemistry, University of Califomia-San Diego, 9500 Gilman Drive, Lajolla, CA 92093-0358... 

The authors thank past and current members of the Stemweis research team for their hard work and contribution to some of the concepts expressed in this chapter and support from the National Institutes of Health (GM31954), the Welch Foundation (1-1262), and the Alfred and Mabel Gilman Chair in Molecular Pharmacology. 

Goodman and Gilman The Pharmacological Basis of Therapeufidfith ed., by Joel G Hardman, Lee E. Limbird, Alfred Goodman, and Gilman (eds.), McGraw Hill, 2001. 

Louis Goodman and Alfred Gilman, The Pharmacological Basis of Therapeutics (New York Macmillan, 1941), pp. 923-927. See also James E. Robbers, Marilyn K. Speedie, and Varro E. Tyler, Pharmacognosy and Pharmacobiotech-nology (Baltimore Williams and Wilkins, 1996), pp. 155-158. 

Alfred Gilman Professor of Pharmacology and Epidemiology Yale University School of Medicine... 

Goodman Gilman s, The Pharmacological basis of therapeutics,9Ul ed, Joel G. Hardman, Alfred Goodman Gilman s, Lee E. Limbird 1996. 

Louis Goodman and Alfred Gilman use nitrogen mustard to treat a patient with non-Hodgkin s lymphoma, inducing tumor regression... 

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