Gigartina skottsbergii

The Pursuit of Potent Anti-influenza Activity from the Antarctic Red Marine Alga Gigartina skottsbergii... 

Fig. 1.2 a Microtiter plate illustrating dose response activity of an extract of the red alga Gigartina skottsbergii (A4) as weU as unrelated and ineffective extract in well F2. b Plaque reduction assay depicting a marked reduction of virus replication in cells treated with extract A4 (50 p-g/mL) compared with No Drug or the unrelated ineffective extract F2. The effect of A4 is similar to that of the control drug ribavirin... 

Fig. 1.3 Fractionation schemes for extracts from the red alga Gigartina skottsbergii. a The initial classic small molecule isolation scheme and b alternative protein isolation scheme...

Fig. 1.4 Hemagglutination assay results from the active fraction of the red alga Gigartina skottsbergii. a Red blood cells (RBCs) hemagglutinate in the presence of influenza virus top row) and with extract A4 -t- virus or extract A4 alone. The bottom two rows present the back titration of the virus used in this experiment, b In contrast to the other anti-influenza drugs (ribavirin, amantadine, rimantadine, and zanamivir) that do not induce hemagglutination of human as well as chicken RBCs, extract A4 does it in a dose-dependent manner...

Fig. 1.5 Percentage protection results for combination drug assays using extract of the red alga Gigartina skottsbergii PSC07-52-A-I (A4) at 8.8 tg/mL with (a) zanamivir at 2.5 tg/mL alone and in combination with PSC07-52-A-I and (b) ribavirin at 2.5 p.g/mL alone and in combination with PSC07-52-A-I...

Carlucci MJ, Pujol CA, Ciancia M, Noseda MD, Matulewicz MC, Damonte EB, Cerezo AS (1997) Antiherpetic and anticoagulant properties of carrageenans from the red seaweed Gigartina skottsbergii and their cyclized derivatives correlation between structure and biological activity. Int J Biol Macromol 20 97-105... 

Pujol CA, Scolaro LA, Ciancia M, Matulewicz MC, Cerezo AS, Damonte EB (2006) Antiviral activity of a carrageenan from Gigartina skottsbergii against intraperitoneal murine Herpes simplex virus infection. Planta Med 72 121-125... 

Gigartina skottsbergii and their cyclized derivatives Correlation between structure and biological activity, Int. J. Biol. Macromol., 20 (1997) 97-105. 

Ciancia, M. 1994. Estudio de los carragenanos de plantas cistocarpicas del alga roja Gigartina skottsbergii. Ph. D. Thesis, University of Buenos Aires, Buenos Aires, Argentina. 

Ciancia, M., Matulewicz, M. C., Cerezo, A. S. (1997). An unusual L-galactose containing carrageenan from cystocarpic Gigartina skottsbergii Phytochemistry, 45,1009-1013. 

Noseda, M. D. (1994). Polissacarideos sulfatados da fase tetrasporofitica de Gigartina skottsbergii (Rhodophyta, Gigartinales). Ph. D. Thesis, Universidade Federal do Parana, Curitiba, Brasil. 

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